Results 91 to 100 of about 196 (129)
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Cognitive Enhancer Noopept Activates Transcription Factor HIF-1
Doklady Biochemistry and Biophysics, 2020The effect of noopept (N-phenylacetyl-L-prolyl-glycine ethyl ester) on the DNA-binding activity of HIF-1 in SH-SH5Y cells and the mechanisms of stabilization of this transcription factor were studied in vitro. Noopept was shown to increase both the basal DNA-binding activity of HIF-1 and the activity induced by various hypoxia mimetics.
L F Zainullina +2 more
exaly +3 more sources
Immunopharmacological properties of noopept
Bulletin of Experimental Biology and Medicine, 2007Noopept, a peptide analog of piracetam, enhanced phagocytic activity of mouse peritoneal macrophages, stimulated humoral and cellular immune response to various antigens, and markedly increased spontaneous proliferative activity of splenocytes. In animals with secondary immune deficiency caused by cyclophosphamide, noopept exhibited immunocorrector ...
A V Pronin, A D Dürnev, S B Seredenin
exaly +3 more sources
Noopept Normalizes Parameters of the Incretin System in Rats with Experimental Diabetes
Bulletin of Experimental Biology and Medicine, 2014Experiments on adult Wistar rats with streptozotocin-induced diabetes showed that antihyperglycemic activity of an original nootropic and neuroprotective drug Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) is more pronounced under conditions of oral application than after intraperitoneal injection.
R U Ostrovskaya +2 more
exaly +3 more sources
Drug with Neuroprotective Properties Noopept Does Not Stimulate Cell Proliferation
Bulletin of Experimental Biology and Medicine, 2019Effects of Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) on the relative level of proliferation marker Ki-67 and cell cycle parameters were studied in HEK293 and SH-SY5Y cell lines. The previously established multifactorial mechanism of action of the drug includes enhancement of neurotrophin NGF and BDNF expression and increase in HIF-1 activity.
L F Zainullina +2 more
exaly +3 more sources
Modulation of Nicotinic Receptors in Neurons in the Common Snail by Noopept and Piracetam
Neuroscience and Behavioral Physiology, 2019The nootropic agents noopept and piracetam alter the amplitudes of acetylcholine-induced influx currents (ACh currents) in command neurons in the common snail. Both compounds have cholinopositive activity. The dose curve of the actions of noopept is bell-shaped, while the piracetam dose-response curve in the range of physiological concentrations shows ...
G B Murzina +2 more
exaly +2 more sources
Studies of long-term noopept and afobazol treatment in rats with learned helplessness neurosis
Bulletin of Experimental Biology and Medicine, 2006Long-lasting effects of new Russian psychotropic drugs Noopept and Afobazol on active avoidance conditioning and formation of learned helplessness neurosis were studied on an original experimental model in rats. Noopept eliminated the manifestations of learned helplessness after long-term (21-day) treatment by increasing the percent of trained animals.
V P Fisenko, Fisenko V P
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Novel nootropic dipeptide Noopept increases inhibitory synaptic transmission in CA1 pyramidal cells
Neuroscience Letters, 2010Effects of newly synthesized nootropic and anxiolytic dipeptide Noopept on inhibitory synaptic transmission in hippocampal CA1 pyramidal cells were investigated using patch-clamp technique in whole-cell configuration. Bath application of Noopept (1 microM) significantly increased the frequency of spike-dependant spontaneous IPSCs whereas spike ...
Rodion V Kondratenko, V G Skrebitsky
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Modulation of the Acetylcholine-Induced Input Current by Noopept in Helix Lucorum Neurons
Biophysics (Russian Federation), 2019Abstract—Possible causes of the positive modulating effect of noopept (in a concentration range of 0.1 to 10 nM) on the amplitude of the acetylcholine-induced input current are analyzed using a developed mathematical model. The results revealed that the calculated and experimental current curves coincide when the number of nicotinic acetylcholine ...
A S Pivovarov, Pivovarov A S
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NOOPEPT – PROTEKCINIŲ SAVYBIŲ TURINTIS PREPARATAS
Health Sciences, 2022Pagrindai ir tikslai. Didėjantis nootropinių preparatų populiarumas ir vartojamas susijęs su didėjančiu nootropų tyrimų duomenų kiekiu. Noopept naujų tyrimų kiekis nėra itin didelis, tačiau jo populiarumas tarp vartotojų nemenkas. Šio straipsnio tikslas yra peržvelgti vaisto noopept tyrimus, siekiant nurodyti šio vaisto potencialą ir naujų tyrimų ...
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[The original novel nootropic and neuroprotective agent noopept].
Eksperimental'naia i klinicheskaia farmakologiia, 2003The paper describes pharmacological properties of the new nootropic drug noopept created using an original approach based on the imitation of a nonpeptide nootrope structure by means of the short-peptide design. In particular, the structure of pyracetam was designed using dipeptide nootropes.
R U, Ostrovskaia +3 more
openaire +2 more sources