Results 51 to 60 of about 7,371 (206)

A Novel Functional Ingredient Derived From a Mixture of Mulberry (Morus alba L.) Leaves and Butterfly Pea (Clitoria ternatea L.) Flowers Enhances Rapid Eye Movement Sleep, Cognitive Function, and Anxiolytic Behavior via GABAA Receptor‐Dependent Mechanism in Rats

Oxidative Medicine and Cellular Longevity, Volume 2026, Issue 1, 2026.
The neuropharmacological benefits for sleep quality and mental health from the extracts of Morus alba L. leaves (MA) and Clitoria ternatea L. flowers (CT) have been revealed previously. However, due to synergistic interactions of polyherbal ingredients, the positive effects of MA mixed with CT are still controversial. Preliminary outcomes from in vitro
Jakkrit Nukitram, Aonvara Kanjanavattana, Panlekha Rungruang, Nattaporn Yotyatthai, Pannita Kaewudom, Pichayapa Promkasikorn, Patharakan Kaowsuwan, Nobuhiro Zaima, Dania Cheaha, Wipawee Thukhammee, Jintanaporn Wattanathorn, Josep Rubert   +11 more
wiley   +1 more source

Novel Sunifiram-carbamate hybrids as potential dual acetylcholinesterase inhibitor and NMDAR co-agonist: simulation-guided analogue design and pharmacological screening

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
An efficient method for synthesising NMDAR co-agonist Sunifiram (DM235), in addition to Sunifram-carbamate and anthranilamide hybrids, has been developed in high yields via protecting group-free stepwise unsymmetric diacylation of piperazine using N ...
Khalid A. Agha, Nader E. Abo-Dya, Abdul Rashid Issahaku, Clement Agoni, Mahmoud E. S. Soliman, Eatedal H. Abdel-Aal, Zakaria K. Abdel-Samii, Tarek S. Ibrahim   +7 more
doaj   +1 more source

Effect of short time captopril administration on spatial memory in aging rats [PDF]

, 2015
Introduction: The brain renin-angiotensin system (RAS) has been reported having a pathological role in age-related impairment in learning and memory. Therefore, angiotensin converting enzyme inhibitors (ACEi) are expected to have positive ef fects on ...
Bakhshandeh, F., Ganji, F., Sepehri, H.
core  

A real‐world survey of the diagnostic journey, current treatment, and burden of mild cognitive impairment or dementia due to Alzheimer's disease in China

Alzheimer's &Dementia, Volume 21, Issue S6, December 2025.
Abstract Background We aimed to describe the diagnostic journey, current treatment, caregiving needs, and burden of patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia in China. Method Data were drawn from the Adelphi Real World AD Disease Specific Programme™, a cross‐sectional survey of neurologists and their patients ...
Jiawei Xin, Hanxi Zhang, Shuang Cai, Jinnan Li, Guanshen Dou, Brenda Botello Estrada, Chloe Walker, Xiaochun Chen   +7 more
wiley   +1 more source

Advances in Pharmacological Insights of Borago officinalis: A Comprehensive Review

Biological Diversity, Volume 2, Issue 4, Page 193-205, December 2025.
ABSTRACT Recent growth in phytotherapy and product‐based drug development has increased interest in this plant because of its broad pharmacological activity. This review aims to examine the pharmacological activities, mechanisms, and potential applications of Borago officinalis, focusing on its primary bioactive constituents and therapeutic ...
Zahra Sufwan, Javed Akhtar Ansari, Farogh Ahsan   +2 more
wiley   +1 more source

Structure‐Guided Identification and Evaluation of Epalrestat and Ranirestat‐Like Compounds Against Aldose Reductase: Therapeutic Management of Diabetic Neuropathy

ChemistryOpen, Volume 14, Issue 12, December 2025.
Structure‐based virtual screening of PubChem compounds identifies two novel epalrestat and ranirestat‐like inhibitors with improved affinity and pharmacokinetic profiles targeting aldose reductase. Molecular docking, ADMET filtering, and 500‐ns molecular dynamics simulations confirm the stability and interaction specificity of the candidates ...
Mohd Shahnawaz Khan, Dharmendra Kumar Yadav, Moyad Shahwan, Anas Shamsi   +3 more
wiley   +1 more source

Dynamic changes of the EEG structure during treatment of the ishaemic insult in the frame of the conception of nootropic stimulation

Бюллетень сибирской медицины, 2008
New approach to treatment of the ishaemic insult (IsI) was developed in the frame of the conception of nootropic stimulation, which include carrying out of nootropic agent (piracetam) with melaxen (analog of endogenous melatonin).
N. S. Kovalyova, V. A. Balyasin, Yu. S. Maklyakov   +2 more
doaj   +1 more source

Herbal Remedies for Combating Irradiation: a Green Antiirradiation Approach [PDF]

, 2014
Plants play important roles in human life not only as suppliers of oxygen but also as a fundamental resource to sustain the human race on this earthly plane.
Choong, Y. S., Deivanai, S., Lachumy, S. J., Latha, L. Y., Oon, C. E., Saravanan, D., Sasidharan, S., Vijayarathna, S., Yeng, C.   +8 more
core   +1 more source

Therapeutic strategies in vascular cognitive impairment: A systematic review and meta‐analysis

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION Vascular cognitive impairment (VCI) is a common, heterogeneous condition, currently lacking approved treatments. METHODS We reviewed therapeutic strategies tested in VCI and meta‐analyzed efficacy data for eligible interventions to assess whether previously tested treatments warranted reconsideration.
Federico Masserini, Claudia Gendarini, Giacomo Baso, Emilia Salvadori, Leonardo Pantoni   +4 more
wiley   +1 more source

Ethical Underpinning and Implications of “Nootropic” Concept

Acta Universitatis Lodziensis: Folia Philosophica, 2018
The current generation paving the path for new research marks a milestone to attain the ancient goal of improving our cognition. To date, increased prevalence of cognitive enhancers by healthy people has raised the scientific community’s attention as ...
Pranab Rudra
doaj   +1 more source