Results 51 to 60 of about 101,642 (221)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Advances in Horticultural Science, 2015 Superficial scald is a disorder developed in cold storage by ‘Conference’ and ‘Abbé Fétel’ pears and it has been related to the presence of oxidation products, mainly conjugated trienols (CTols), of which α-farnesene is primary, acting on epidermal cells.
M. Vanoli +4 more
doaj +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Information for Social Change, 1994 What do mangoes and eggs have to do with a library conference about emerging democracies? They emerged as symbols of capitalism and communism during the International Group of the Library Association's weekend school.
John Pateman
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
AUSTRALIA’S PARTICIPATION AND PERFORMANCE AT THE EVIAN CONFERENCE: INTEGRITY OR SHAME?
Vestnik MGIMO-Universiteta, 2018 This article outlines and assesses the contribution made by the Commonwealth of Australia to the Evian Conference of July 1938. The attitude of the Australian government, it will be shown, was ambivalent from the start, with the Commonwealth not even ...
P. R. Bartrop
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Safety-oriented bicycling and traffic accident involvement
IATSS Research, 2018 Many U.S. bicyclists are killed or injured in traffic accidents annually. Based on analysis of available research and published reports on traffic accidents, it was theorized that adherence to six safety-oriented on-road bicycling practices will reduce ...
Mark W. Hoglund
doaj +1 more source