Results 211 to 220 of about 424,277 (296)
Circulating levels of insulin‐like growth factor I (IGF‐I) and risk of multiple myeloma: An observational and Mendelian randomisation study
British Journal of Haematology, EarlyView.Summary
Evidence for an association between insulin‐like growth factors (IGF) and multiple myeloma (MM) is inconsistent. We examined total IGF‐I concentrations and risk of MM by combining baseline serological data among UK Biobank participants (n = 444 187; 732 incident MM) with a two‐sample Mendelian randomisation (MR) analysis using identified ...Yolanda Benavente, Sara Hermosa, Nikos Papadimitriou, Alyssa Clay‐Gilmour, Elizabeth E. Brown, Jonathan N. Hofmann, Nathaniel Rothman, Qing Lan, Sonja I. Berndt, Demetrius Albanes, Mark Purdue, Mitchell J. Machiela, Stephen J. Chanock, Parveen Bhatti, Wendy Cozen, Aaron Norman, Susan L. Slager, James R. Cerhan, Vincent Rajkumar, Shaji K. Kumar, Celine M. Vachon, Anne J. Novak, Thomas M. Habermann, Brian K. Link, Gilles Salles, Herve Ghesquieres, Paige M. Bracci, Elizabeth Holly, Rosalie G. Griffin, Michelle A. T. Hildebrandt, Roel C. H. Vermeulen, P. Martijn Kolijn, Henrik Hjalgrim, Karin Ekström Smedby, Harindra Jayasekara, Simon Cheah, Alain Monnereau, Yu Chen, Alan Arslan, Yawei Zhang, Nicola J. Camp, Douglas W. Sborov, Afaf E. G. Osman, Elad Ziv, Immaculata De Vivo, Vijai Joseph, Lauren R. Teras, Alpa V. Patel, Eleanor Kane, Claire M. Vajdic, Adrien Guilloteau, Pierluigi Cocco, Laia Alemany, Juan Sainz, James McKay, Brenda M. Birmann, Delphine Casabonne +56 morewiley +1 more sourceCorrection: Community preferred drug delivery approaches for pilot roll-out of a potential novel paediatric schistosomiasis treatment option in two endemic counties of Kenya: A mixed methods study. [PDF]
PLOS Glob Public HealthMasaku J, Gachohi JM, Sinkeet A, Maghanga M, Wakesho F, Omondi W, Monnier N, Steinmann P, Reigl LS, Lange IL, Winkler AS, Njenga SM, Amuyunzu-Nyamongo M. +12 moreeuropepmc +1 more sourceCost‐effectiveness of percutaneous nephrostomy vs JJ stent in obstructive urolithiasis: economic evaluation alongside the STent Or NEphrostomy (STONE) randomised controlled trial
BJU International, EarlyView.Objective
To evaluate whether percutaneous nephrostomy (PCN) is cost‐effective compared to JJ ureteric stent in the acute treatment of obstructive urolithiasis. Patients and Methods
A randomised controlled non‐inferiority trial with 204 patients with obstructive urolithiasis requiring decompression.Hugo W. Schuil, Nora Hendriks, Mohamed El Alili, Judith E. Bosmans, Ruben G. Duijnhoven, Bart C.H. Oskam, Tom J.H. Arends, Diederick Duijvesz, Alexander D. Horsch, Bart van der Heij, Irene Tjiam, Hans van Overhage, Armand B.G.N. Lamers, Otto M. van Delden, Wout Scheepens, Jamie M.A. Drossaerts, Frank C.H. d'Ancona, Steven Boering, Janneke I.M. van Uhm, Rutger W. van der Meer, Herman J.H. van Roijen, Martin de Kiefte, Ad J.M. Hendrix, Saskia Weltings, Rob C.M. Pelger, Harrie P. Beerlage, Guido M. Kamphuis, Barbara M.A. Schout +27 morewiley +1 more sourcePatient‐reported outcome measures of percutaneous nephrostomy vs JJ stent in obstructive urolithiasis: results of the STent Or NEphrostomy (STONE) randomised controlled trial
BJU International, EarlyView.Objective
To compare the effects of percutaneous nephrostomy (PCN) and JJ ureteric stent (JJ) for urinary tract decompression in patients with obstructive urolithiasis on health‐related quality of life (HRQoL), pain scores, urinary symptoms, and patient satisfaction.Hugo W. Schuil, Nora Hendriks, Ruben G. Duijnhoven, Bart C. H. Oskam, Tom J. H. Arends, Diederick Duijvesz, Alexander D. Horsch, Bart van der Heij, Irene M. Tjiam, Hans van Overhagen, Armand B. G. N. Lamers, Otto M. van Delden, Wout A. Scheepens, Jamie M. A. Drossaerts, Frank C. H. d'Ancona, Steven Boering, Janneke I. M. van Uhm, Rutger W. van der Meer, J. Herman van Roijen, Martin de Kiefte, Ad J.M. Hendrikx, Saskia Weltings, Rob C. M. Pelger, Harrie P. Beerlage, Barbara M. A. Schout, Guido M. Kamphuis +25 morewiley +1 more sourceThe L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains
Brain Pathology, EarlyView.A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla +20 morewiley +1 more sourceCorrection: Ethics of HIV cure research: an unfinished agenda. [PDF]
BMC Med EthicsDubé K, Kanazawa J, Taylor J, Dee L, Jones N, Roebuck C, Sylla L, Louella M, Kosmyna J, Kelly D, Clanton O, Palm D, Campbell DM, Onaiwu MG, Patel H, Ndukwe S, Henley L, Johnson MO, Saberi P, Brown B, Sauceda JA, Sugarman J. +21 moreeuropepmc +1 more sourceModulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress
British Journal of Pharmacology, EarlyView.Background and Purpose
Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo +9 morewiley +1 more source
