Results 71 to 80 of about 5,649,103 (354)

Unlocking bacterial defense: Exploring the potent inhibition of NorA efflux pump by coumarin derivatives in Staphylococcus aureus.

open access: yesMicrobial Pathogenesis
The occurrence of bacterial resistance has been increasing, compromising the treatment of various infections. The high virulence of Staphylococcus aureus allows for the maintenance of the infectious process, causing many deaths and hospitalizations.
Ana Luíza A.R. Martin   +15 more
semanticscholar   +1 more source

Active Phase of Nickel Electrocatalysts Driving Alkaline Hydrogen Evolution

open access: yesAdvanced Materials, EarlyView.
Using depth‐resolved and operando spectroscopic measurements coupled with electrochemical mass spectrometry, the authors uncover the critical role of sub‐surface oxidised species in increasing the activity and durability of Ni‐based cathodes for hydrogen evolution.
Yifeng Wang   +17 more
wiley   +1 more source

Cardiac bridging integrator 1 gene therapy rescues chronic non-ischemic heart failure in minipigs

open access: yesnpj Regenerative Medicine
Heart failure (HF) is a major cause of mortality and morbidity worldwide, yet with limited therapeutic options. Cardiac bridging integrator 1 (cBIN1), a cardiomyocyte transverse-tubule (t-tubule) scaffolding protein which organizes the calcium handling ...
Jing Li   +12 more
doaj   +1 more source

An exciting Approach to Theoretical Spectroscopy

open access: yesAdvanced Science, EarlyView.
ABSTRACT Theoretical spectroscopy, and more generally, electronic‐structure theory, are powerful concepts for describing the complex many‐body interactions in materials. They cover methods from ground‐state properties to lattice excitations and light‐matter interaction, including time‐resolved variants.
Martí Raya‐Moreno   +29 more
wiley   +1 more source

AAV9-cBIN1 gene therapy rescues chronic heart failure due to ischemic cardiomyopathy in a canine model

open access: yesCommunications Medicine
Background Ischemic cardiomyopathy and resultant heart failure (HF) is a significant cause of morbidity and mortality worldwide. Downregulation of cardiac bridging integrator 1 (cBIN1), a membrane scaffolding protein responsible for organizing t-tubules ...
Muhammad S. Khan   +16 more
doaj   +1 more source

NorA efflux pump mediates Staphylococcus aureus response to Pseudomonas aeruginosa pyocyanin toxicity

open access: yesAntimicrobial Agents and Chemotherapy
Endogenous transporters protect Staphylococcus aureus against antibiotics and also contribute to bacterial defense from environmental toxins. We evaluated the effect of overexpression of four efflux pumps, NorA, NorB, NorC, and Tet38, on S.
Q. C. Truong-Bolduc   +4 more
semanticscholar   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

open access: yesAdvanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau   +22 more
wiley   +1 more source

Nora Haimberger Senior Recital, June 26, 1959 [PDF]

open access: yes, 1959
Concert program for Nora Haimberger Senior Recital, June 26 ...

core  

Current Collector Engineering for New Efficient Bioresorbable Sodium‐Ion Batteries

open access: yesAdvanced Science, EarlyView.
A bioresorbable Na‐ion battery is proposed with Mo or Mg thin‐film current collectors for temporary implants. Mo‐based batteries exhibit superior electrochemical performance and stable cycling compared with Mg counterparts. XPS was used to investigate the Mo/Mg surface oxidation.
Bincy Lathakumary Vijayan   +15 more
wiley   +1 more source

Expanded Phenotype Associated With an Intronic PPP1R12A Variant: A Case Report and Literature Review

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal dominant PPP1R12A‐related genitourinary and/or brain malformation syndrome is a recently described multisystem disorder caused by loss‐of‐function variants in the protein phosphatase 1 regulatory subunit 12a (PPP1R12A) gene. To date, 22 affected individuals have been reported with variable brain malformations and genitourinary ...
Emily M. Bland   +4 more
wiley   +1 more source

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