Results 191 to 200 of about 138,491 (253)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Efficacy of iodine-131-metaiodobenzylguanidine therapy for multiple endocrine neoplasia type 2A-associated metastatic pheochromocytoma: case report and literature review. [PDF]

Endocr J
Suda K, Kimura N, Maeda T, Watanabe S, Nishida S, Shima H, Sugawara T, Uchino S, Ishikawa A, Tanaka T, Furuhashi M, Masumori N, Sakurai A.   +12 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

The Neurochemical Orchestra of the Runner's High: A Narrative Review of Neuromodulatory Mechanisms with a Focus on Endocannabinoids. [PDF]

Neuroscientist
Siebers M, Canales-Romero D, Fuss J.
europepmc   +1 more source

Predicting Acute Kidney Injury After Lung Transplantation: Development and Internal Validation of Perioperative Prediction Models. [PDF]

Clin Transplant
Trevena S, Snell GI, Westall GP, Asghari-Jafarabadi M, Shulman MA, Coulson TG.   +5 more
europepmc   +1 more source

Efficacy and safety of different vasopressor infusions on feto-maternal outcomes in normotensive patients undergoing caesarean delivery: a systematic review and network meta-analysis of randomised controlled trials. [PDF]

Anaesthesia
Singh NP, Makkar JK, Khurana BJK, Borle A, Singh PM.   +4 more
europepmc   +1 more source

The Role of the Nervous System in Lung Disease. [PDF]

Curr Neurol Neurosci Rep
Mawer CMA, Patel A, Zeltner N, Glassberg Csete MK, Herzog EL.   +4 more
europepmc   +1 more source