Results 131 to 140 of about 101,853 (190)

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, EarlyView.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source

Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light

Medicinal Research Reviews, EarlyView.
ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva, Carlo Matera, Silvia Roda, Alessio Colleoni, Marco De Amici, Pau Gorostiza   +5 more
wiley   +1 more source

PGC‐1α Activation by Polyphenols: A Pathway to Thermogenesis

Molecular Nutrition &Food Research, EarlyView.
Polyphenols, derived from dietary sources such as berries, undergo digestion and interact with gut microbiota, leading to their metabolization in the liver. This process influences bile acid composition, which in turn activates PGC1α, a key regulator of mitochondrial biogenesis and thermogenesis.
Nicholas Vannuchi, Luciana Pisani
wiley   +1 more source

Differential Effects of Wild Blueberry (Poly)Phenol Metabolites in Modulating Lipid Metabolism and Oxidative Stress in 3T3‐L1 Adipocytes

Molecular Nutrition &Food Research, EarlyView.
Metabolites derived from wild blueberry (poly)phenols, such as syringic (SA), vanillic (VA), and isoferulic acids (IA), can modulate lipid metabolism and oxidative stress markers in mature 3T3‐L1 adipocytes treated with free fatty acids (FFAs; oleic/palmitic acid, 750 µM, 2:1 ratio).
Samuele Venturi, Marco Rendine, Mirko Marino, Dorothy Klimis‐Zacas, Patrizia Riso, Cristian Del Bo'   +5 more
wiley   +1 more source

Perioperative hemodynamic parameters monitored by three noninvasive technologies in children with congenital heart disease: A prospective study

Pediatric Discovery, EarlyView.
ROC curves illustrates the predictive value of parameters obtained from three methods in predicting any of the AEs. AEs, adverse events; FPR, false positive rate; TPR, true positive rate; 1 (LVEFmea line overlaps with LVEFmin line); 2 (SVRImea line overlaps with SVRImin line); 3 (SVRImea line, SVRImin line, and LVEFmea line overlap); 4 (SVRImea line ...
Xiaoyu Xiong, Feng Xu, Wei Qiu, Shaojun Li, Chengjun Liu   +4 more
wiley   +1 more source

Horner syndrome in a pediatric patient

Pediatric Investigation, EarlyView.
Horner syndrome (HS) is a rare neurological disorder arising from disruption of the oculosympathetic pathway. paediatric HS is uncommon and may be congenital, however it is imperative that underlying sinister causes are excluded. ABSTRACT Introduction Horner syndrome (HS) is a rare neurological disorder arising from disruption of the oculosympathetic ...
Devansh Tandon, Matthew Azzopardi, Dominic Fenn, Mira Parmar, Saurabh Jain   +4 more
wiley   +1 more source

Pharmacokinetic and pharmacodynamic evaluation of sulbactam‐durlobactam in a critically ill patient on continuous venovenous hemofiltration infected with carbapenem‐resistant Acinetobacter baumannii‐calcoaceticus complex

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
Abstract Background Drug databases currently do not provide dosing guidance for sulbactam‐durlobactam in continuous renal replacement therapy. Herein, we present the first in vivo pharmacokinetic (PK) evaluation of sulbactam‐durlobactam during continuous venovenous hemofiltration (CVVH) in a patient with carbapenem‐resistant Acinetobacter baumannii ...
Wesley D. Kufel, Nabil Zeineddine, Aliaa Fouad, Hanna F. Roenfanz, Ryan K. Shields, Ellen G. Kline, Jameson Warner, Kathleen Hanrahan, Joseph L. Kuti   +8 more
wiley   +1 more source

Low‐value interventions to deimplement: A secondary analysis of a systematic review of low back pain clinical practice guidelines

PM&R, EarlyView.
Abstract Objective To perform a secondary review of low back pain (LBP) clinical practice guidelines (CPG) identified in a recently conducted systematic review and to synthesize and summarize low‐value recommendations as practices that may be candidates for deimplementation.
Daniel Tai, Eunyeop Kim, Prateek Grover, Alejandro Rodriguez, Timothy J. Olivier, Thiru M. Annaswamy   +5 more
wiley   +1 more source

Pharmacotherapy for Cirrhosis in Japan

Portal Hypertension &Cirrhosis, EarlyView.
As cirrhosis progresses from the compensated to the decompensated stage, liver disease‐related events such as varices, ascites, encephalopathy, sarcopenia, jaundice, and bleeding tendency, as well as liver carcinogenesis, can occur at a high rate. With the advent of new pharmacotherapies for cirrhosis in the last decade, liver fibrosis has been shown ...
Hiroki Nishikawa, Soo Ki Kim, Akira Asai
wiley   +1 more source

Objective short sleep duration is associated with elevated blood pressure in depression: The autonomic nerve dysfunction effect

Sleep Research, EarlyView.
Abstract The relationship between sleep disturbance, autonomic nerve dysfunction, and blood pressure in patients with major depressive disorder (MDD) was unclear. We studied 66 patients with MDD and 66 age‐matched and sex‐matched controls. Objective and subjective sleep were assessed using the polysomnography and Pittsburgh Sleep Quality Index ...
Baixin Chen, Wenli Ban, Yanyuan Dai, Le Chen, Jun Wu, Dandan Zheng, Jiansheng Zhang, Yun Li   +7 more
wiley   +1 more source