The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Cerebral ischemia–reperfusion injury (CI/RI) is a major cause of secondary neuronal damage following ischemic stroke. This study investigated whether terazosin (TZ) exerts neuroprotective effects by regulating mitophagy and the reactive oxygen species (ROS)/NOD‐like receptor protein 3 (NLRP3) inflammasome axis.
Wei Wang +5 more
wiley +1 more source
Impact of Early versus Delayed Vasopressin Initiation on 28-Day Mortality in Older Adults with Septic Shock. [PDF]
Ther Clin Risk ManagLiu L, Shi H, Zhang L, Ma J.
europepmc +1 more source
Pregabalin Efficacy in Treatment of Chronic Neurogenic Cough
The Laryngoscope, EarlyView.The use of neuromodulators for chronic cough has increased; however, the choice of medication, dosing regimen, and duration are still unclear. This longitudinal study of 95 adults taking pregabalin, 75 mg twice daily, for CNC demonstrated 78% improvement or resolution of cough, 17% unchanged, 1% worse cough, with a mean of 6 weeks of therapy, and only ...
Jacqui Allen +3 more
wiley +1 more source
Alcohol and Stress Together Can Lead to Long-Term, Dementia-Like Deleterious Effects in the Brain. [PDF]
Alcohol Clin Exp Res (Hoboken)Sergio TO, Hopf FW.
europepmc +1 more source
Hypotensive Episodes Precede Cognitive Fluctuations in Parkinson's Disease Dementia
Movement Disorders Clinical Practice, EarlyView.Abstract Background Cognitive fluctuations (CFs) are a disabling feature in Parkinson's disease dementia (PDD) and contribute to caregiver burden. The relationship between CFs and neurogenic orthostatic hypotension (nOH), a common autonomic complication in PDD, has not been adequately examined.
Jorge Patino +6 more
wiley +1 more source
Cardiac MIBG Scintigraphy in Neurodegenerative Parkinsonism: Limitations in Clinical Practice
Movement Disorders Clinical Practice, EarlyView.Abstract Background Reduced cardiac uptake on 123Iodine‐metaiodobenzylguanidine (MIBG) scintigraphy is a valuable tool for differentiating neurodegenerative parkinsonism but interpretation can be difficult due to comorbidities and drug‐tracer interactions.
Frank Jagusch +9 more
wiley +1 more source
Endothelial Activation and Stress Index as an Indicator of Early Hemodynamic Instability in Critically Ill Patients: A Single-Centre Observational Study. [PDF]
Diagnostics (Basel)Kreczko MJ +3 more
europepmc +1 more source
Living with the Unknown: Intolerance of Uncertainty in Parkinson's Disease
Movement Disorders Clinical Practice, EarlyView.Abstract Background Parkinson's disease (PD) is marked by pervasive uncertainty due to fluctuating motor and non‐motor symptoms, variable treatment response, and an unpredictable clinical course. Intolerance of uncertainty (IU), a tendency to perceive ambiguity as threatening and respond with worry, avoidance, or decisional paralysis, may be ...
Bradley McDaniels +3 more
wiley +1 more source
Determining the ED90 of prophylactic phenylephrine and norepinephrine infusions for higher blood pressure target maintenance during cesarean delivery: a randomized sequential allocation trial. [PDF]
Front PharmacolShi Y, Ma R, Ma Y, Xi N, Chen Y.
europepmc +1 more source