Results 91 to 100 of about 36,448 (236)

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Organization of the Locus Coeruleus-Norepinephrine System [PDF]

, 2015
The release of the neurotransmitter norepinephrine throughout the mammalian brain is important for modulating attention, arousal, and cognition during many behaviors.
Luo, Liqun, Schwarz, Lindsay A.
core   +1 more source

Synthesis of Aminocyclopropanes by Redox‐Neutral Aminoalkylation

Angewandte Chemie International Edition, EarlyView.
Aminocyclopropane synthesis by hydroaminoalkylation utilizing cheap, readily available starting materials is presented, offering orthogonality to commonly used methods and allowing broad functional‐group tolerance. Solvent‐mediated conditions enable the reaction of a pre‐formed hemiaminal with alkenes and alkynes.
Gwyndaf A. Oliver, Konstantin Günther, Chiara Sebastianelli‐Schoditsch, Sophie Woolford, Iina Ludwig, Harald H. Sitte, Nuno Maulide   +6 more
wiley   +1 more source

Amphetamine and the Smart Drug 3,4-Methylenedioxypyrovalerone (MDPV) Induce Generalization of Fear Memory in Rats

Frontiers in Molecular Neuroscience, 2019
Human studies have consistently shown that drugs of abuse affect memory function. The psychostimulants amphetamine and the “bath salt” 3,4-methylenedioxypyrovalerone (MDPV) increase brain monoamine levels through a similar, yet not identical, mechanism ...
Paola Colucci, Paola Colucci, Giulia Federica Mancini, Giulia Federica Mancini, Alessia Santori, Alessia Santori, Clemens Zwergel, Clemens Zwergel, Antonello Mai, Viviana Trezza, Benno Roozendaal, Benno Roozendaal, Patrizia Campolongo, Patrizia Campolongo   +13 more
doaj   +1 more source

Thermoregulation and Norepinephrine [PDF]

Science, 1969
R D, Meyers, M A, Simmonds, L L, Iversen
openaire   +2 more sources

Atypical Attentional Effort During Visual Search in Autistic Adults: Evidence From Task‐Evoked Pupillary Responses

Autism Research, EarlyView.
ABSTRACT According to prevalent views, autistic individuals have a stronger tendency to allocate attention to details, as supported by reports of enhanced visual search performance. However, both the dynamics and the types of information involved in attentional guidance in autism are not fully understood.
Zainab Naaran, Amit Yashar
wiley   +1 more source

Zebrafish Get Connected: Investigating Neurotransmission Targets and Alterations in Chemical Toxicity

Toxics, 2016
Neurotransmission is the basis of neuronal communication and is critical for normal brain development, behavior, learning, and memory. Exposure to drugs and chemicals can alter neurotransmission, often through unknown pathways and mechanisms.
Katharine A. Horzmann, Jennifer L. Freeman   +1 more
doaj   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Elevated blood plasma levels of epinephrine, norepinephrine, tyrosine hydroxylase, TGFβ1, and TNFα associated with high-altitude pulmonary edema in Indian population

, 2016
Priyanka Pandey,1,2 Zahara Ali,1,2 Ghulam Mohammad,3 MA Qadar Pasha1,2 1Functional Genomics Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, 2Department of Biotechnology, Savitribai Phule Pune University, Pune, 3Department of Medicine ...
Mohammad G, Pasha MAQ, Pandey P, Ali Z
core