Results 71 to 80 of about 238,380 (247)

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Melatonin and monoaminergic system – behavioural aspects [PDF]

Romanian Journal of Neurology, 2016
Melatonin, the hormone synthesized mainly by the pineal gland, is a key member of the complex monoaminergic signaling system, and a circadian regulator with pleiotropic functions.
S.E. Voiculescu, A. Rosca, C.M.D. Zahiu, C. Badiu, A.M. Zagrean   +4 more
doaj   +1 more source

Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats [PDF]

, 2018
Introduction: There has been an increasing interest in analyzing the interactions between stimulants and ethanol during childhood and adolescence. Stimulants are used to treat attention-deficit hyperactivity disorder (ADHD) in these developmental stages,
Acevedo, Adriani, Aleksandrov, Andersen, Atianjoh, Berardo, Brandon, Brunelle, Burke, Camarini, Chong, Crawford, Crowley, Cryan, Dalsgaard, Diaz Heijtz, Doremus-Fitzwater, Duke, Fahlke, Feltmann, Fernandez, Frey, Frolov, Gaytan, Gaytan, Gaytan, Gaytan, Gill, Gowin, Heinz, Izenwasser, Jones, Justo, Kameda, Karanikas, Karim, Kozanian, Krasnova, Kuczenski, Kuczenski, Lambert, Mandt, Mannuzza, McClintick, McCullough, McDougall, McDougall, Naimi, National-Research-Council, Pascual, Pilatti, Pilatti, Pilatti, Pinsky, Ponce, Quinn, Quinn, Renard, Ruiz, Salisbury, Schenk, Schuckit, Schuckit, Soeters, Spear, Spear, Sripada, Stewart, Strakowski, Tirelli, Vendruscolo, Venkataraman, Venniro, Wagner, Wetzell, Wille-Bille, Winer, Wolgin   +77 more
core   +1 more source

Transcutaneous vagus nerve stimulation does not affect verbal memory performance in healthy volunteers [PDF]

, 2020
Introduction: Invasive vagus nerve stimulation (VNS) improves word recognition memory in patients with epilepsy. Recent studies with transcutaneous VNS (tVNS) have also shown positive effects on various subdomains of cognitive functioning in healthy ...
Boon, Paul, Carrette, Evelien, Gadeyne, Stefanie, Mertens, Ann, Miatton, Marijke, Naert, Lien, Poppa, Tasha, Raedt, Robrecht, Vonck, Kristl   +8 more
core   +1 more source

Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone

Advanced Science, EarlyView.
In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman, Gurcharan Kaur, Serra Kaya, Joanna Bons, Carlos Galicia Aguirre, Qi Liu, Christina D. King, Kenneth A. Wilson, Harrison L. Baker, Mikayla Hady, Nadja Maldonado Luna, Gregor Bieri, Saul A. Villeda, Lisa M. Ellerby, Birgit Schilling, Tamara Alliston   +15 more
wiley   +1 more source

Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue [PDF]

, 2007
In response to cold, norepinephrine (NE)-induced triacylglycerol hydrolysis (lipolysis) in adipocytes of brown adipose tissue (BAT) provides fatty acid substrates to mitochondria for heat generation (adaptive thermogenesis).
Bianco, Antonio C., Christoffolete, Marcelo A., D'Eon, Tara M., Greenberg, Andrew S., Imachi, Hitomi, Miyoshi, Hideaki, Obin, Martin S., Perfield, James W., II, Ribeiro, Miriam O., Rogers, Nicole H., Souza, Sandra C., Stancheva, Zlatina S., Strissel, Katherine J.   +12 more
core   +1 more source

Neuromodulator Dynamics Underlying Associative Learning in the Ventral Striatum's Olfactory Tubercle

Advanced Science, EarlyView.
Using fiber photometry and genetically encoded sensors, the dynamic release patterns of four neuromodulators in the olfactory tubercle (OT)—a brain region overlapping with the olfactory cortex and ventral striatum—were systematically monitored in response to external rewards and distinct reward‐associated learning processes.
Maojun Hong, Liuting Zou, Yiqing Chen, Juan Guo, Zhixiang Xu, Tong Ma, Shuaishuai Hu, Rongfeng K. Hu   +7 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Stress reactivity and its relationship to beef quality in Nguni steers supplemented with Acacia karroo leaves

Animal, 2011
The objective of this study was to determine the levels of catecholamines and their relationship to beef quality in Nguni steers fed on Acacia karroo leaves. A total of 30 19-month-old steers were randomly assigned to A.
C. Mapiye, M. Chimonyo, M.C. Marufu, V. Muchenje   +3 more
doaj   +1 more source

Single prazosin infusion in prelimbic cortex Fosters extinction of amphetamine-induced conditioned place preference [PDF]

, 2017
Exposure to drug-associated cues to induce extinction is a useful strategy to contrast cue-induced drug seeking. Norepinephrine (NE) transmission in medial prefrontal cortex has a role in the acquisition and extinction of conditioned place preference ...
Alessandro Rava, Emanuele C. Latagliata, Giulia Chiacchierini, Luisa Lo Iacono, Luisa Lo Iacono, Marco Sancandi, Stefano Puglisi-Allegra, Stefano Puglisi-Allegra, Valeria Oliva   +8 more
core   +4 more sources