Results 71 to 80 of about 176,090 (288)
, 1985 Paraventricular (PVN) hypothalamic norepinephrine (NE) injections which facilitated feeding were nonetheless found to reduce both the unconditioned preference for saccharin and starch-conditioned preferences for almond odor and lemon taste, as well as ...
J W Matthews (16222829) +2 more
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Animal Models and Experimental Medicine, EarlyView.Baihe Zhimu Decoction alleviates anxious depression‐like behaviors and protects hippocampal neurons. Chemical profiling and network pharmacology reveal multiple active components acting via the PI3K/AKT/mTOR pathway, enhancing neuronal survival and function, as confirmed by multi‐level in vitro and in vivo validation.
Yuanshan Han +8 more
wiley +1 more source
Noradrenergic Dysfunction in Alzheimer's and Parkinson's Diseases—An Overview of Imaging Studies
Frontiers in Aging Neuroscience, 2018 Noradrenergic dysfunction contributes to cognitive impairment in Alzheimer's Disease (AD) and Parkinson's Disease (PD). Conventional therapeutic strategies seek to enhance cholinergic and dopaminergic neurotransmission in AD and PD, respectively, and few
Andrew C. Peterson +4 more
doaj +1 more source
Advanced NanoBiomed Research, EarlyView.Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang +12 more
wiley +1 more source
Testing whether drugs that weaken norepinephrine signaling prevent or treat various types of cancer
, 2009 Paul J FitzgeraldThe Zanvyl Krieger Mind/Brain Institute, Solomon H. Snyder, Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USAAbstract: Recently, I put forth the hypothesis that the signaling molecule, norepinephrine (NE), is an ...
Paul J Fitzgerald
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Synthesis of Aminocyclopropanes by Redox‐Neutral Aminoalkylation
Angewandte Chemie International Edition, EarlyView.Aminocyclopropane synthesis by hydroaminoalkylation utilizing cheap, readily available starting materials is presented, offering orthogonality to commonly used methods and allowing broad functional‐group tolerance. Solvent‐mediated conditions enable the reaction of a pre‐formed hemiaminal with alkenes and alkynes.
Gwyndaf A. Oliver +6 more
wiley +1 more source
Noradrenergic Modulation of Fear Conditioning and Extinction
Frontiers in Behavioral Neuroscience, 2018 The locus coeruleus norepinephrine (LC-NE) system plays a broad role in learning and memory. Here we begin with an overview of the LC-NE system. We then consider how both direct and indirect manipulations of the LC-NE system affect cued and contextual ...
Thomas F. Giustino, Stephen Maren
doaj +1 more source
Influence of Anesthetics on the Myocardial Sensitization 2. Exogenous Norepinephrine. [PDF]
Isolated cat atria were used to study the effect of anesthetics on the uptake of added (exogenous) norepinephrine. Increased atrial rate of beating in response to a given concentration of norepinephrine was unaffected by halothane, methoxyflurane ...
内藤, 裕史
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British Journal of Clinical Pharmacology, EarlyView.SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić +7 more
wiley +1 more source