Results 151 to 160 of about 36,448 (236)

Hormone therapy (HT) in women with premature ovarian insufficiency or early menopause: Time to think of a new paradigm for healthy aging. A joint FIGO and IMS position paper

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and ...
Chiara Benedetto, Suvarna S. Khadilkar, Rossella E. Nappi, Andrea R. Genazzani, Federica Frezet, Laura Cucinella, Hema Divakar, Panagiotis Anagnostis, Nick Panay   +8 more
wiley   +1 more source

Anxiety disorder and anxiolytic pharmacotherapy during pregnancy: The impact on pregnancy outcomes

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study determines the contributions of anxiety disorder and anxiolytic pharmacotherapy on perinatal outcomes and examines prescribing trends during pregnancy. Methods A retrospective cohort study was conducted at a single tertiary medical center between 2013 and 2024.
Sher Goaz Melet, Chagit Kliger, Daniel Gabbai, Danna Englender, Yariv Yogev, Omri Dominsky   +5 more
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Tissue Clearing for Lymph Nodes: 3D Mapping of Nerves and the Immune Microenvironment

iNew Medicine, EarlyView.
ABSTRACT Lymph nodes (LNs) are central hubs of adaptive immunity and key relay sites for metastatic tumour cells. However, conventional two‐dimensional histology samples only a small fraction of each node, potentially missing micrometastases and multifocal involvement while obscuring long‐range spatial relationships among tumour deposits, immune ...
Guang‐Hong Su, Fei Wang, Ting‐Hong Wei, Rui Lu, Wen‐Jun Huang, Xiang Zhang, Ling Yin, Jun Li   +7 more
wiley   +1 more source

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

Interdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang, Junge Chen, Jiao Xia, Weitong Yang, Teng Ma, Tianzi Shan, Weifeng He, Gaoman Zhang, Zhuoran Xia, Weiwei Wang, Zhusheng Liu, Zhiqiang Yi, Piye Niu, Tian Chen   +13 more
wiley   +1 more source

Incidental Detection of Portal Venous Gas During POCUS in a Neonate With Necrotizing Enterocolitis and Intestinal Perforation: A Case Report

Journal of Clinical Ultrasound, EarlyView.
Point‐of‐care ultrasound performed at the bedside identified hepatic portal venous gas in a critically ill neonate, prompting urgent evaluation and revealing intestinal perforation due to necrotizing enterocolitis. This case highlights the potential of POCUS to accelerate diagnosis when clinical signs are subtle or nonspecific.
Tiago Henrique de Souza, Elisa Caixeta Fallieri Nascimento, Fernando de Lima Carioca, Nayara Hillebrand Franzon, Humberto Magalhães Silva   +4 more
wiley   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Terazosin Attenuates Neuronal Pyroptosis by Regulating the Mitochondrial ROS/NLRP3 Inflammasome Axis Through Mitophagy in Cerebral Ischemia–Reperfusion Injury

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Cerebral ischemia–reperfusion injury (CI/RI) is a major cause of secondary neuronal damage following ischemic stroke. This study investigated whether terazosin (TZ) exerts neuroprotective effects by regulating mitophagy and the reactive oxygen species (ROS)/NOD‐like receptor protein 3 (NLRP3) inflammasome axis.
Wei Wang, Xin‐Yue Han, Li‐An Huang, Yu‐Sheng Zhang, Heng Meng, An‐Ding Xu   +5 more
wiley   +1 more source

Non‐Linear Threshold Effect of Dynamic Estimated Plasma Volume Status on Revealing In‐Hospital Mortality Risk in Sepsis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This retrospective cohort study evaluated the association between estimated plasma volume status (ePVS) and in‐hospital mortality in adult patients with sepsis from the MIMIC‐IV (v2.2) database. After excluding patients with early death, readmission, red blood cell transfusion, malignancy, or missing ePVS data, 17,403 patients meeting Sepsis‐3
Zhi‐An Si, Sheng‐Bing Xia, Yang Zou, Xiao‐Yan Wang   +3 more
wiley   +1 more source

Pregabalin Efficacy in Treatment of Chronic Neurogenic Cough

The Laryngoscope, EarlyView.
The use of neuromodulators for chronic cough has increased; however, the choice of medication, dosing regimen, and duration are still unclear. This longitudinal study of 95 adults taking pregabalin, 75 mg twice daily, for CNC demonstrated 78% improvement or resolution of cough, 17% unchanged, 1% worse cough, with a mean of 6 weeks of therapy, and only ...
Jacqui Allen, Carmen Esna, Camille Prigent, Anna Miles   +3 more
wiley   +1 more source