Results 161 to 170 of about 135,584 (242)

Critically Ill Children Show Disrupted Sleep Patterns and Atypical Electroencephalograms: An Observational Cohort Study

Acta Paediatrica, EarlyView.
ABSTRACT Aim Sleep disruptions are common in hospitalised children. This study described sleep in critically ill and non‐critically ill hospitalised children, including young infants and patients with central nervous system injuries. Methods This observational cohort study included two groups: critically ill children admitted to a paediatric intensive ...
Eris van Twist, Arnout B. G. Cramer, Sascha C. A. T. Verbruggen, Maartje Louter, Karlien Veldscholte, Koen F. M. Joosten, Matthijs de Hoog, Karla Biesheuvel, Dirk C. G. Straver, Rogier C. J. de Jonge   +9 more
wiley   +1 more source

Serum neurotransmitter imbalances in benign paroxysmal positional vertigo: correlations with anxiety, depression, and sleep quality. [PDF]

Front Neurol
Zhang Q, She R, Zhou H, Guo J, Hu Z.
europepmc   +1 more source

Brain viral reservoir seeding and neurological metabolic dysregulation in early‐life immunodeficiency virus infection

Brain Pathology, EarlyView.
Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma, Robert Blair, Yao‐Zhong Liu, Xiaolei Wang, Eunice Vincent, Christopher Yu, Lara A. Doyle‐Meyers, Cissy Zhang, Ahmad Saied, Anne Le, Ronald S. Veazey, Qigui Yu, Huanbin Xu   +12 more
wiley   +1 more source

Homovanillic acid and vanillylmandelic acid as neuroblastoma biomarkers in children. [PDF]

Biochem Med (Zagreb)
Kavalakatt S, Ivica J.
europepmc   +1 more source

Clinicopathological and molecular heterogeneity of amyloid‐β in unnatural deaths under 70 years: A forensic autopsy–based study

Brain Pathology, EarlyView.
This study investigates amyloid‐beta (Aβ) pathology in a forensic autopsy cohort of relatively young individuals (40–69 years). Using detailed immunohistochemical analyses of multiple Aβ species, we demonstrate marked regional and molecular heterogeneity, particularly within the striatum.
Shojiro Ichimata, Yukiko Hata, Koji Yoshida, Ryo Tanaka, Shigeo Murayama   +4 more
wiley   +1 more source

Baseline alignment and resuscitation exposure in hemodynamic phenotyping of septic shock. [PDF]

Crit Care
Qian Y, Zhang J, Chen J, Wu W.
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Attitudes, opinions and practice patterns regarding anaesthesia providers' use of vasopressors: protocol for a multicentre mixed-methods study. [PDF]

BMJ Open
Janda AM, Mirizzi K, Athavale T, Mathis MR, Dubovoy T, Cocroft S, Chen T, Alrubaie N, Kheterpal S, Guetterman T.   +9 more
europepmc   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source