Results 221 to 230 of about 236,485 (262)

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

The FEBS Journal, EarlyView.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova, Caroline M. Ferreira, Katrina P. Montales, Francisco Villalobos, Alexandra J. Brownstein, Rebeca Acín‐Pérez, Gabrielly S. Ferreira, Anthony E. Jones, Linsey Stiles, Ajit S. Divakaruni, Marc Liesa, Orian S. Shirihai, Marcus F. Oliveira   +12 more
wiley   +1 more source

Individualized intraoperative blood pressure control with norepinephrine reduces kidney injury biomarkers but not creatinine-defined acute kidney injury in older patients with hypertension undergoing major abdominal surgery: a single-center randomized controlled trial. [PDF]

BMC Anesthesiol
Li J, Jiang H, Song QL, Jiang ZM, Liu S.
europepmc   +1 more source

Novel optimization of multi‐mechanistic approaches for the acute treatment of a migraine attack: A review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To highlight key factors required to optimize multi‐mechanistic approaches with oral combination treatments for the acute management of a migraine attack. Background Given the complex multi‐factorial nature of migraine, combining treatments with different mechanisms of action should improve outcomes compared to monotherapies, but ...
Stephen Silberstein, Alan M. Rapoport
wiley   +1 more source

Subphenotyping hypotension in early sepsis: A physiology-guided therapeutic approach. [PDF]

Ann Intensive Care
Sanchez E C, Teboul JL.
europepmc   +1 more source

Healthcare Professionals' Perceptions of Artificial Intelligence in Healthcare—A Systematic Review of Qualitative Studies

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To identify the experiences and perceptions of healthcare professionals on artificial intelligence in healthcare. Design Systematic literature review of qualitative studies and meta‐aggregation. Data Sources CINAHL, PubMed, Scopus, Medic and ProQuest were systematically searched on December 9, 2024. Results Twenty‐six studies were included
Huotari Sini, Mikkonen Kristina, Jarva Erika, Suonnansalo Petra, Kaikkonen Assi, Lee Jay Jung Jae, Oikarinen Anne   +6 more
wiley   +1 more source

Trajectories of mean arterial pressure/norepinephrine equivalent dose index in patients with septic shock receiving low-dose hydrocortisone: a retrospective cohort study in Thailand. [PDF]

Acute Crit Care
Chalermwutanon A, Saejaow S, Vattanavanit V.   +2 more
europepmc   +1 more source

Annual Research Review: Neural mechanisms of eating disorders in youth – from current theory and findings to future directions

Journal of Child Psychology and Psychiatry, EarlyView.
Eating disorders are prevalent and profoundly debilitating psychiatric conditions with multifactorial etiology that frequently manifest during adolescence. This developmental stage is characterized by significant neurostructural and neurofunctional change, which may create a context conducive to the emergence of eating pathology.
Kelsey Hagan, E. Caitlin Lloyd, Sasha Gorrell   +2 more
wiley   +1 more source

Venlafaxine-Associated Takotsubo Cardiomyopathy Complicated by Cardiogenic Shock and Left Ventricular Outflow Tract Obstruction: A Case Report and Literature Review. [PDF]

Acta Cardiol Sin
Wu YJ, Yeh CF, Lin PC, Hung CS.
europepmc   +1 more source

Pregabalin efficacy in painful diabetic peripheral neuropathy: A focused analysis of optimal dosing and the relationship of baseline glycemic control

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Introduction Diabetic neuropathy, the most common long‐term complication of diabetes, frequently presents as painful diabetic peripheral neuropathy (pDPN), significantly impairing patients' quality of life. Pregabalin is an established treatment for pDPN, but optimal dosing and the influence of glycemic control on efficacy remain uncertain ...
Ashish Bajaj, Gordon Sloan, Chris Walker, Egbert Biesheuvel, Sagar Suresh Kumbhar, Gavin Lyndon, Solomon Tesfaye   +6 more
wiley   +1 more source