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Effect of norepinephrine uptake blockers on norepinephrine kinetics
Clinical Pharmacology and Therapeutics, 1981We studied the effect of a single oral dose of the neuronal norepinephrine uptake blocker, desipramine 125 mg, on norepinephrine kinetics. Desipramine reduced the plasma norepinephrine clearance by approximately 20%, from 1.33 +/- 0.22 to 1.08 +/- 0.19 l/m2/min (p less than 0.01).
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