Results 211 to 220 of about 176,090 (288)

Pharmacokinetics of tramadol and O‐desmethyltramadol in healthy dogs after a single oral dose of 2 mg/kg

Australian Veterinary Journal, EarlyView.
Tramadol exposure after low oral doses is variable in dogs, and the estimation of the terminal phase can be difficult when late concentrations plateau or rebound. This study characterized tramadol and O‐desmethyltramadol (M1) after a single oral dose of 2 mg/kg in 10 healthy female mixed‐breed dogs.
YDB Passos, NS Fernandes, KN Arcoverde, AN Mouta, R dos Anjos Honorato, G Araujo‐Silva, VV de Paula   +6 more
wiley   +1 more source

Use of selective serotonin reuptake inhibitors and risk of myeloid malignancy: A nationwide Danish case–control study

British Journal of Haematology, EarlyView.
Summary Preclinical and clinical studies suggest that selective serotonin reuptake inhibitors (SSRIs) can stimulate haematopoiesis by promoting proliferation and mobilization of haematopoietic stem and progenitor cells, but whether SSRI use influences myeloid malignancy risk remains unclear.
Katrine Mose, Anton Pottegård, Mette Reilev, Christen Lykkegaard Andersen, Blánaid Hicks, Mathilde Egelund Christensen   +5 more
wiley   +1 more source

A regularised latent‐class item response model for detecting measurement non‐invariance in ordinal response scales

British Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract Measurement non‐invariance arises when the psychometric properties of a scale differ across subgroups, undermining the validity of group comparisons. At the item level, this manifests as differential item functioning (DIF), where item responses differ across groups after controlling for the latent trait.
Gabriel Wallin, Qi Huang
wiley   +1 more source

Association of oXiris Hemoadsorption with Inflammatory, Hemodynamic, Respiratory, and Organ Dysfunction Parameters in Patients with Sepsis and Septic Shock in the Intensive Care Unit: A Retrospective Comparative Cohort Study. [PDF]

Life (Basel)
Orhan S, Ay M, Ay M, Gulsoy KY.
europepmc   +1 more source

Clinicopathological and molecular heterogeneity of amyloid‐β in unnatural deaths under 70 years: A forensic autopsy–based study

Brain Pathology, EarlyView.
This study investigates amyloid‐beta (Aβ) pathology in a forensic autopsy cohort of relatively young individuals (40–69 years). Using detailed immunohistochemical analyses of multiple Aβ species, we demonstrate marked regional and molecular heterogeneity, particularly within the striatum.
Shojiro Ichimata, Yukiko Hata, Koji Yoshida, Ryo Tanaka, Shigeo Murayama   +4 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Effects of sympathomimetic agents on heart rate variability during general anesthesia in Thoroughbred horses. [PDF]

J Equine Sci
Ohmura H, Boscan P, Jones JH, Steffey EP.   +3 more
europepmc   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Morphological changes in the arterial pressure waveform following hemodynamic therapies in critical care: A clinical proof-of-concept study in older adults. [PDF]

Physiol Rep
de Raat FM, Mulder MP, Dekker AJRB, Bouwman AR, Montenij LJ, Donker DW.   +5 more
europepmc   +1 more source