Results 191 to 200 of about 176,090 (288)

Low-concentration norepinephrine in the French operating theatre: A study of daily practices and pharmacological dosages in real-life conditions. [PDF]

Eur J Anaesthesiol Intensive Care
Iraqi M, Vallée F, Mateo J, Mebazaa A, Weiss E, Oliary J, Callebert J, Cartailler J, Joachim J.   +8 more
europepmc   +1 more source

Psilocybin in alcohol use disorder and comorbid depressive symptoms: Results from a feasibility randomized clinical trial

Addiction, EarlyView.
Abstract Background and Aims Psilocybin has emerged as a potential treatment for alcohol use disorder (AUD), but early efficacy data are inconsistent. Depression following alcohol detoxification significantly increases the risk of relapse. This pilot study aimed to evaluate the feasibility, acceptability, and preliminary efficacy of psilocybin‐assisted
Amandine Luquiens, Dahbia Belahda, Carine Graux, Noe Igounenc, Chris Serrand, Paul Rochefort, Thibault Mura, Felix Sergent   +7 more
wiley   +1 more source

Centanafadine (Simtriyo®): a first-in-class triple reuptake inhibitor approved for attention-deficit/hyperactivity disorder (ADHD). [PDF]

Med Chem Res
Hu L.
europepmc   +1 more source

Comparative effectiveness, safety and acceptability of pharmacological and psychosocial interventions for the treatment of cannabis use disorder: A network meta‐analysis

Addiction, EarlyView.
Abstract Aim Our primary aim was to conduct a network meta‐analysis (NMA) for the effectiveness, safety and acceptability of all psychosocial interventions and all pharmacotherapies for cannabis use disorder (CUD). Methods We conducted a NMA of studies identified from two completed systematic reviews examining the effectiveness, safety and ...
Monika Halicka, Francesca Spiga, Tom P. Freeman, Suzanne Nielsen, Jelena Savović, Julian P. T. Higgins, Deborah M. Caldwell   +6 more
wiley   +1 more source

Vasopressor-Associated Limb Ischemia Resulting in Quadruple Amputation in Suspected Septic Shock. [PDF]

Clin Case Rep
Rubens M, Ramamoorthy V, Shah K, Rodriguez A, Murillo B, Muniz KL, Saxena A, McGranaghan P, Sanjar T.   +8 more
europepmc   +1 more source

Opioid Prescribing Changes in Advanced Cancer Before and After Withdrawal of Hydromorphone Slow‐Release Tablets

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Hydromorphone slow‐release tablet withdrawal from the Australian market altered opioid prescribing patterns in advanced cancer pain. Methadone use increased by nearly 50% and median doses doubled. There may be a need to tailor clinician training on safe and effective use of methadone and other opioids as appropriate. ABSTRACT Aim Ongoing disruptions to
Aaron K. Wong, Helen McManus, Sara Vogrin, Youseph Dib, Monnette Samo, Jonathan La, Brian Le, Jennifer Philip   +7 more
wiley   +1 more source

Early multimodal vasopressor strategy in septic shock: results of the TRICYCLE randomized controlled trial. [PDF]

Crit Care
Kalamar Ž, Landoni G, Gorenjak M, Cestar I, Fluher J, Horvat M, Jerenec K, Kit B, Marinšek M, Puklavec N, Svenšek F, Radonić R, Šundalić S, Brajković AV, Vujević A, Erjavc N, Petek D, Košir AS, Homšak E, Knehtl MC, Markota A.   +20 more
europepmc   +1 more source

Time‐Resolved Multi‐Omics Identify Biomarkers of Immediate Reactions to mRNA Vaccination

Allergy, EarlyView.
We compared early vaccine‐induced immune and metabolic signatures and downstream immunity after second and booster BNT162b2 doses in participants with sARs, ISSRs, or no reactions. Neutrophil mobilization, antiviral programs, and robust anti‐S‐antibody responses occurred across reaction groups.
Ana Olivera, Benjamin Schwarz, Brittany Dulek, Ian S. LaCroix, Min Li, Lindsay Chatman, Muhammad B. Khalid, Ellen Zektser, Karen Laky, Stella Hartono, Eric Bohrnsen, Cole D. Kimzey, Eric Chu, Roa Harb, Pamela A. Frischmeyer‐Guerrerio   +14 more
wiley   +1 more source

Severity-stratified vasopressor-escalation strategies in septic shock: a cross-fitted doubly robust analysis with external replication. [PDF]

Front Pharmacol
Zhang Y, Han M, Liu X, Chen G, Zhang L.
europepmc   +1 more source