Results 191 to 200 of about 135,584 (242)

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

The FEBS Journal, EarlyView.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova, Caroline M. Ferreira, Katrina P. Montales, Francisco Villalobos, Alexandra J. Brownstein, Rebeca Acín‐Pérez, Gabrielly S. Ferreira, Anthony E. Jones, Linsey Stiles, Ajit S. Divakaruni, Marc Liesa, Orian S. Shirihai, Marcus F. Oliveira   +12 more
wiley   +1 more source

From Stress to Neurodegeneration: A New Look at the Pathogenesis of Parkinson's Disease. [PDF]

Biomedicines
Kazanskaya RB, Tsytsarev V, Volnova AB, Gainetdinov RR, Lopachev AV.   +4 more
europepmc   +1 more source

Fast & fuelious: the malate–aspartate shuttle in brown adipocyte lipid metabolism

The FEBS Journal, EarlyView.
Brown adipose tissue (BAT) produces heat in response to cold exposure, for which it relies on the coordination of aerobic and anaerobic metabolism. However, how reaction intermediates connect these two essential pathways is unclear. In this issue of The FEBS Journal, Veliova et al., report that the malate–aspartate shuttle (MAS) supports norepinephrine‐
Lukas Blaas, Alexander Bartelt
wiley   +1 more source

Noradrenergic inhibition of definitive POMC neurons through direct and indirect mechanisms. [PDF]

J Neuroendocrinol
Lavoie O, Turmel A, Khouma A, Minbashi Moeini M, Liu C, Michael NJ, Caron A.   +6 more
europepmc   +1 more source

Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice

The FEBS Journal, EarlyView.
Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan, Caroline Uslucan, Aleyna Kizilyer, Samet Agca, Aylin Karatas, Sanaz Naghizadeh, Bahar Zehra Camurdanoglu Weber, Sukru Anil Dogan, Serkan Kir   +8 more
wiley   +1 more source

Reply to: comments on "The effects of norepinephrine in shockable cardiac arrest, a scoping review". [PDF]

Scand J Trauma Resusc Emerg Med
Bouman SJM, Baldussu E, Franssen GHLM, van Geffen GJ, Bruhn J, Slagt C, Mommers LPW.   +6 more
europepmc   +1 more source

Mean Arterial Pressure Augmentation for Acute Traumatic Spinal Cord Injury: A Systematic Review and Meta-Analysis of Neurological Recovery and Mortality. [PDF]

Global Spine J
Kale KM, Patel S, Nischal SA, Ceccon L, Heller J, Jallo J, Harrop JS, Prasad SK.   +7 more
europepmc   +1 more source

Comparison of vasopressin-first weaning versus norepinephrine-first weaning in critically ill patients. [PDF]

Int J Clin Pharmacol Ther
Alshreef M, AbaAlkhayl H, Almdainy Q, Alshammari A, Alajmi S, Alruwaite S, Alqahtani E, Almalke R, Alonazi T.   +8 more
europepmc   +1 more source

Extracorporeal Cytokine Hemadsorption for the Treatment of Severe Steroid Refractory Cytokine Release Syndrome Secondary to T-Cell Immunotherapy for B-Cell Malignancies: A Case Series. [PDF]

Hematol Oncol
Cavallaro G, Ferrari S, Pollastri A, Di Credico E, Meli C, Rondi M, Putelli A, Lussana F, Grassi A, Rambaldi A, Valetti TM, Riva I, Gritti G.   +12 more
europepmc   +1 more source