Results 121 to 130 of about 2,727 (172)
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Clinical Endocrinology, 1979
SUMMARYSingle oral doses of 0.3 mg, 0.5 mg and 5 mg Norethindrone (NET) and 0.5 mg and 5 mg Lynestrenol (lyn) were given to five women. Lynestrenol is probably metabolized through NET and exerts its main biological activity as NET. Plasma concentrations of NET were determined by a radioimmunoassay at different intervals after administration of the ...
V, Odlind +3 more
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SUMMARYSingle oral doses of 0.3 mg, 0.5 mg and 5 mg Norethindrone (NET) and 0.5 mg and 5 mg Lynestrenol (lyn) were given to five women. Lynestrenol is probably metabolized through NET and exerts its main biological activity as NET. Plasma concentrations of NET were determined by a radioimmunoassay at different intervals after administration of the ...
V, Odlind +3 more
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Contraception, 1978
A specific radioimmunoassay was developed for the estimation of norethindrone levels in the serum of lactating women. A conjugate of norethindrone-3-BSA was synthesized and antiserum raised against it in rabbits. The antiserum showed high affinity (1.5 x 10(9)M/L) and titer and was specific. The sensitivity of the assay was 125 pg/ml serum.
V, Laumas +6 more
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A specific radioimmunoassay was developed for the estimation of norethindrone levels in the serum of lactating women. A conjugate of norethindrone-3-BSA was synthesized and antiserum raised against it in rabbits. The antiserum showed high affinity (1.5 x 10(9)M/L) and titer and was specific. The sensitivity of the assay was 125 pg/ml serum.
V, Laumas +6 more
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Pharmacokinetics of norethindrone in Indian women
Contraception, 1979Pharmacokinetics of norethindrone (NET) was evaluated in eleven women belonging to a low socio-economic group and in five womem belonging to the high socio-economic group after the administration of an oral dose of 0.35 mg NET minipill on an empty stomach. Blood samples were collected at different intervals of time over a period of 24 hours. Plasma NET
K V, Prasad +3 more
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Structure of the Isonicotinyl Hydrazone of Norethindrone
Journal of Pharmaceutical Sciences, 1983The contraceptive steroid norethindrone reacts with isoniazid both in vivo and in vitro to give the corresponding hydrazone, which exists as syn and anti (with respect to C-4) isomers. These isomers rapidly interconvert, with the anti form predominating in solution.
K, Bailey, A, Menzies, H, Watanabe
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Contraception, 1991
Subdermal silastic implants releasing norethindrone acetate were inserted in five rhesus monkeys for a period of seven months. The serum norethindrone (NET) levels were estimated from blood samples collected fortnightly. There was an initial high level of NET followed by fluctuating levels of NET in 4 out of five monkeys.
P, Jha, K, Murugesan, A, Farooq
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Subdermal silastic implants releasing norethindrone acetate were inserted in five rhesus monkeys for a period of seven months. The serum norethindrone (NET) levels were estimated from blood samples collected fortnightly. There was an initial high level of NET followed by fluctuating levels of NET in 4 out of five monkeys.
P, Jha, K, Murugesan, A, Farooq
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Norethindrone with Estrogen as an Oral Contraceptive
Southern Medical Journal, 1963The major properties and contraceptive efficacy of progestational hormones are reviewed. The effectiveness of these hormones is compared with that of other modern methods of contraception and results of a study involving the use of norethindrone in low dosage in conjunction with a small quantity of estrogen are presented.
W P, HUTCHERSON, H A, SCHWARTZ, L, SMITH
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[Pharmacokinetics of norethindrone-3-oxime and norethindrone in rhesus monkeys].
Yao xue xue bao = Acta pharmaceutica Sinica, 1991After intravenous administration or nasal feeding of (6, 7-3H)-labelled norethindrone-3-oxime (NETO) or norethindrone (NET) to rhesus monkeys, the serum concentrations were determined by measuring the radioactivity after separation with HPLC. The serum concentrations of total extractable radioactivity were also measured without HPLC separation.
G M, Fu +8 more
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Subdermal norethindrone pellets — A method for contraception?
Contraception, 1979The mode of action of compressed pellets containing 85 per cent norethindrone (NET) and 15 per cent cholesterol was studied. Four pellets were inserted subcutaneously, in each of five healthy volunteers and left in place for 200--229 days. The NET content of the pellets varied between 23.9 mg and 25.6 mg; and the cholesterol content between 4.2 mg and ...
V, Odlind +4 more
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Norethindrone plasma levels in human subjects
Life Sciences, 1974Abstract An analytical procedure for the estimation of norethindrone (17β-hydrox-19-nor-17α-pregn-4-en-20-yn-3-one) in human plasma has been developed. After extraction and purification on a silver ion exchange column, norethindrone is converted to a methoxime-trimethylsilyl ether derivative and measured by a gas chromatograph-mass spectrometer ...
C E, Cook +6 more
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Contraception, 1995
Subdermal Silastic implants releasing norethindrone (NET) were inserted in five rhesus monkeys for a period of seven months. The total length of the implants used was 160 mm (eight implants of 20 mm each) containing 160 mg of NET (1 mg NET/mm). The in vivo release rate of NET from the Silastic implants containing 160 mg NET was 3.12 micrograms/day/mm ...
P, Jha, K, Murugesan, A, Farooq
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Subdermal Silastic implants releasing norethindrone (NET) were inserted in five rhesus monkeys for a period of seven months. The total length of the implants used was 160 mm (eight implants of 20 mm each) containing 160 mg of NET (1 mg NET/mm). The in vivo release rate of NET from the Silastic implants containing 160 mg NET was 3.12 micrograms/day/mm ...
P, Jha, K, Murugesan, A, Farooq
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