Results 21 to 30 of about 2,270 (113)
Clinical and Translational Science, Volume 18, Issue 4, April 2025.ABSTRACT This study assessed the effect of cladribine tablets (CladT) on the pharmacokinetics (PK) of a combined oral contraceptive (COC) in pre‐menopausal women with relapsing multiple sclerosis. It was a randomized, double‐blind, two‐period, two‐sequence crossover study to assess steady‐state plasma PK (area under the concentration–time curve and ...
Robert Hermann +10 more
wiley +1 more source
Prevention of mammary carcinogenesis by short-term estrogen and progestin treatments [PDF]
, 2003 INTRODUCTION: Women who have undergone a full-term pregnancy before the age of 20 have one-half the risk of developing breast cancer compared with women who have never gone through a full-term pregnancy.
Guzman, Raphael C +5 more
core +2 more sources
The Biological Activity of Estrogen-Free Norethindrone
Experimental Biology and Medicine, 1965 Estrogen-free norethindrone (17alpha-ethynyl-17beta-hydroxyestr-4-en-3one) was synthesized and its estrogenic and antiestrogenic activity and fertility and spermatogenetic activity were studied. Norethindrone was found to be .3% as active as estrone by gavage and by subcutaneous injection by a mouse uterotrophic assay.
Fred A. Kincl, Ralph I. Dorfman
openaire +3 more sources
Pharmacology Research &Perspectives, Volume 13, Issue 1, February 2025.Relugolix concentration/time profiles in breast milk of lactating women. ABSTRACT Relugolix is an oral gonadotropin‐releasing hormone receptor antagonist that suppresses sex steroid hormones and is approved as monotherapy for prostate cancer and as a fixed‐dose combination with estradiol/norethindrone for the treatment of endometriosis and uterine ...
Darin B. Brimhall +4 more
wiley +1 more source
Standard Protocols for Characterising Primary and In Vitro‐Generated Human Hepatocytes
Journal of Cellular and Molecular Medicine, Volume 29, Issue 3, February 2025.ABSTRACT Hepatocyte‐like cells (HLCs) derived from pluripotent stem cells (PSCs) or direct reprogramming are an unlimited source of human hepatocytes for biomedical applications. HLCs are used to model human diseases, develop precise drugs and establish groundbreaking regenerative cell‐based therapies.
Zahra Heydari +11 more
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 11, Page 2016-2025, November 2024.Abstract Breakthrough bleeding (BTB) is a common side effect of hormonal contraception and is thought to impact adherence to combined oral contraceptives (COCs) but respective dose–response relationships are not yet fully understood. Therefore, the objective of this model‐based meta‐analysis (MBMA) was to establish dose–response for COCs containing ...
Huili Chen +9 more
wiley +1 more source
The use of molecular descriptors to model pharmaceutical uptake by a fish primary gill cell culture epithelium [PDF]
, 2018 Modelling approaches, such as Quantitative Structure-Activity Relationships (QSARs) use molecular descriptors to predict the bioavailable properties of a compound in biota.
Bury, Nic R. +4 more
core +4 more sources
British Journal of Clinical Pharmacology, Volume 90, Issue 10, Page 2366-2382, October 2024.Transgender persons face a greater burden of HIV compared to cisgender counterparts. Concerns around drug–drug interactions (DDIs) have been cited as reasons for lower engagement in HIV care and lower pre‐exposure prophylaxis (PrEP) uptake among transgender populations.
Tessa Senneker
wiley +1 more source
New approaches for estimating risk from exposure to diethylstilbestrol. [PDF]
, 1999 A subgroup from a National Institute of Environmental Health Sciences, workshop concerned with characterizing the effects of endocrine disruptors on human health at environmental exposure levels considered the question, If diethylstilbestrol (DES) were ...
Cunha, GR +7 more
core +2 more sources
Effect of 7 -Methylation on Biological Activities of Norethindrone
Experimental Biology and Medicine, 1964 SummaryA very substantial increase of oral gonadotropin inhibiting (34 X), pregnancy inhibiting (10 X) and uterotropic (24 X) potencies was observed for 7α-meth-y1-17 α-ethynyl-19-nortestosterone (U-13851) compared to 17-ethynyl-19-nortestosterone (norethindrone) even though progestational potency was not enhanced.
Gordon W. Duncan +2 more
openaire +3 more sources