Results 31 to 40 of about 2,727 (172)

Indications and Efficacy of Progestogen‐Monotherapy as Menopause Hormone Therapy: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Menopausal hormone therapy (MHT) remains the most effective treatment for vasomotor symptoms (VMS) and other manifestations of menopause; however, its use is limited in women with contraindications to oestrogen. Progestogen monotherapy, though historically underutilized, represents a viable alternative in this population. This narrative review
Chloe Thomas, Olivia Carere, Lauren Clarfield, Michelle Jacobson   +3 more
wiley   +1 more source

Integrating transcriptomics and network analysis-based multiplexed drug repurposing to screen drug candidates for M2 macrophage-associated castration-resistant prostate cancer bone metastases

Frontiers in Immunology, 2022
Metastatic castration-resistant prostate cancer (CRPC) has long been considered to be associated with patient mortality. Among metastatic organs, bone is the most common metastatic site, with more than 90% of advanced patients developing bone metastases (
Jinyuan Chang, Zhenglong Jiang, Tianyu Ma, Jie Li, Jiayang Chen, Peizhi Ye, Li Feng   +6 more
doaj   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Evaluation of a Point‐of‐Care Viscoelastic Coagulation Monitor (VCM Vet) and Thromboelastography (TEG) in Bonobos (Pan paniscus)

Journal of Medical Primatology, Volume 55, Issue 4, August 2026.
ABSTRACT Introduction Bonobos (Pan paniscus) are endangered and uncommon in managed care. Prothrombotic and hypofibrinolytic states are encountered with cardiovascular disease, ischemic stroke, and neoplasia. Materials and Methods Twelve bonobos from one institution were evaluated during anesthetized exams.
Megan M. Roeder, Priya Bapodra‐Villaverde, Lauren E. Mumm, Alex M. Lynch, Laura R. Culbreth, Megan L. Cabot, Timothy A. Georoff, Larry J. Minter   +7 more
wiley   +1 more source

Endometriosis: Epidemiology, Risk Factors, Molecular Mechanisms, Diagnosis, and Management

MedComm, Volume 7, Issue 7, July 2026.
Global epidemiology, integrated determinants, and disease burden of endometriosis. This circular schematic comprehensively illustrates the global prevalence and demographic variation of endometriosis, its multifactorial integrated determinants, the multifaceted disease burden and economic impact, and recent epidemiological trends, providing a holistic ...
Kun Wang, Dongyun He, Yang Wang, Xiaojun Liu, Li Liu   +4 more
wiley   +1 more source

Oral Contraceptives and Multiple Sclerosis/Clinically Isolated Syndrome Susceptibility. [PDF]

PLoS ONE, 2016
BACKGROUND:The incidence of multiple sclerosis (MS) is rising in women. OBJECTIVE:To determine whether the use of combined oral contraceptives (COCs) are associated with MS risk and whether this varies by progestin content.
Kerstin Hellwig, Lie H Chen, Frank Z Stancyzk, Annette M Langer-Gould   +3 more
doaj   +1 more source

Occurrence and seasonal distribution of steroid hormones and bisphenol A in surface waters and suspended sediments of Quebec, Canada

Environmental Advances, 2022
Limited information is available regarding the seasonal and spatial distribution of endocrine disrupting compounds (EDCs) in Canadian surface waters. Using improved analytical methods, we set out to evaluate the occurrence and risks of 15 EPA-priority ...
Ken Goeury, Gabriel Munoz, Sung Vo Duy, Michèle Prévost, Sébastien Sauvé   +4 more
doaj   +1 more source

Colorimetric Analysis of Norethindrone, Norethindrone Acetate, and Norgestrel in Oral Contraceptives

Journal of AOAC INTERNATIONAL, 1970
Abstract A colorimetric method, based on reaction with blue tetrazolium, has been devised for the analysis of norethindrone, norethindrone acetate, and norgestrel. The technique is selective for these progestins, showing no interference from the estrogens ethinyl estradiol and mestranol, commonly found in oral contraceptives.
Shuing Carol Liu, Thomas H Hassall, Robert V Smith   +2 more
openaire   +1 more source

A phase 1 study of the breast milk and plasma pharmacokinetics of zavegepant 10 mg intranasal dose in healthy lactating women

Headache: The Journal of Head and Face Pain, Volume 66, Issue 5, Page 1050-1057, May 2026.
Abstract Objective This study evaluated the pharmacokinetics of zavegepant in human breast milk and plasma following a single, 10 mg dose of zavegepant nasal spray. Background Zavegepant nasal spray is a member of the gepant class of medications; small molecule inhibitors of the calcitonin gene‐related peptide receptor.
Abhijeet Jakate, Yan Weng, Ani Shkrodova, Ogert Fisniku, Ding Ding, Kayce Morton, Benjamin Maligalig, Pamela Garnick, Jing Liu, Mohamed H. Shahin   +9 more
wiley   +1 more source

A concept for a new approach to combined oral contraception from adolescence to perimenopause: Continuous use of the oral GnRH antagonist Relugolix and the fetal estrogen Estetrol

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 4, Page 568-574, April 2026.
It is expected that the relugolix estetrol combination RE4W will enable women to control their fertility and prevent menstrual cycle related problems, while offering a smooth transition through perimenopause into the postmenopause and decrease the risk of breast cancer.
Herjan J. T. Coelingh Bennink, Karolina Afors, Luis Bahamondes, Alessandra Graziottin, Deborah Bateson, Teresa Bombas, Yutaki Osuga, Santiago Palacios, Carolyn L. Westhoff, Kristina Gemzell‐Danielsson   +9 more
wiley   +1 more source