Results 11 to 20 of about 2,727 (172)

Bioequivalence of a Fixed-Dose Combination of Relugolix, Estradiol, and Norethindrone Acetate: An Open-Label, Randomized, Fully Replicate Crossover Study in Healthy Postmenopausal Women Under Fasting Conditions. [PDF]

Clin Pharmacol Drug Dev
Abstract Uterine fibroids are the most common benign gynecological tumors, often causing heavy menstrual bleeding (HMB), anemia, and impaired quality of life. A fixed‐dose combination (FDC) of relugolix (40 mg), estradiol (1 mg), and norethindrone acetate (0.5 mg) was developed to address these limitations.
Kotadia R, Kumar S, Khuroo A, Dharmadhikari S, Shahi P, Narayana GNVSS, Reyar S.   +6 more
europepmc   +2 more sources

Considerations for Menstrual Suppression in Patients With Hematologic Malignancies. [PDF]

Pharmacotherapy
ABSTRACT Patients who menstruate during treatment for hematologic malignancies have a higher risk of heavy vaginal bleeding due to thrombocytopenia caused by malignancy and myelosuppressive chemotherapy. Heavy menstrual bleeding is associated with significant morbidity in this patient population, and menstrual suppression is a standard of supportive ...
Veeravalli S, Schepers A, Benitez LL, Fraga MS.   +3 more
europepmc   +2 more sources

Retraction Note: Management of uterine leiomyoma and adenomyosis: role of hysteroscopy in diagnosis and norethindrone in the treatment [PDF]

Scientific Reports
Ahmed Ali, Alaaeldin Youssef, Ali El Saman, Hisham Abou Taleb   +3 more
doaj   +2 more sources

A Comparative Metabolomics Study of the Potential Marker Compounds in Feces from Different Hybrid Offspring of Huainan Pigs [PDF]

Animals
As a notable native Chinese genetic population, the Huainan pig has an exceptional meat quality but a low percentage of lean meat and subpar genetic performance.
Yufu Li, Mingyang Jia, Junfeng Chen, Fujiu Liu, Qiaoling Ren, Xiangzhou Yan, Baosong Xing, Chuanying Pan, Jing Wang   +8 more
doaj   +2 more sources

Elagolix treatment in women with heavy menstrual bleeding associated with uterine fibroid: a systematic review and meta-analysis

BMC Women's Health, 2022
Background Elagolix is effective and safe for treating menorrhagia in women with uterine fibroid. However, it is reported to be associated with hypoestrogenism that can be alleviated by adding estradiol/norethindrone acetate.
Juliawati Muhammad, Yusnita Yusof, Imran Ahmad, Mohd Noor Norhayati   +3 more
doaj   +1 more source

PHARMACOKINETIC STUDY OF NORETHINDRONE COPRECIPITATE [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 1993
Pharmacokinetic parameters of norethindrone (NE) were studied in 12 adult female guinea pigs following either oral or rectal administration of a single dose of 2.5 mg.
S. Safwat, S. Abou-El-Ela
doaj   +1 more source

Norethindrone is superior to combined oral contraceptive pills in short-term delay of menses and onset of breakthrough bleeding: a randomized trial

BMC Women's Health, 2019
Background To determine whether oral norethindrone acetate is superior to combined oral contraceptives (OCP) in delaying menstruation and preventing breakthrough bleeding when started late in the cycle.
Joshua Dean, Katherine J. Kramer, Fauzia Akbary, Shaunte Wade, Maik Hüttemann, Jay M. Berman, Maurice-Andre Recanati   +6 more
doaj   +1 more source

Effects of norethindrone on the growth, behavior, and thyroid endocrine system of adult female western mosquitofish (Gambusia affinis)

Ecotoxicology and Environmental Safety, 2023
Progestins are mainly used in pharmacotherapy and animal husbandry and have received increasing attention as they are widely detected in various aquatic ecosystems.
Yanfang Guo, Xiaorou Liang, Haisheng Li, Meixin Ye, Hong Zou, Hongjun Yu, Tang Qi, Liping Hou, Yan-Qiu Liang   +8 more
doaj   +1 more source

Norethindrone substituted for megestrol in the treatment of metastatic endometrial carcinoma: Three cases

Gynecologic Oncology Reports, 2017
Megestrol is an effective palliative treatment for endometrial carcinoma. Some persons with progestin-responsive cancer continue on hormonal therapy for months or even years.
William L. Read, Sumita Trivedi, Felicia Williams   +2 more
doaj   +1 more source

Intraperitoneal administration of thermosensitive hydrogel Co-loaded with norcantharidin nanoparticles and oxaliplatin inhibits malignant ascites of hepatocellular carcinoma

Drug Delivery, 2022
Malignant ascites is a common complication of some advanced cancers. Although intraperitoneal (IP) administration of chemotherapy drugs is routinely used to treat cancerous ascites, conventional drugs have poor retention and therefore need to be ...
Susu Xiao, Yu Wang, Wenqiong Ma, Ping Zhou, Biqiong Wang, Zhouxue Wu, Qian Wen, Kang Xiong, Yanlin Liu, Shaozhi Fu   +9 more
doaj   +1 more source