Results 81 to 90 of about 3,066 (203)

PhD

, 2008
dissertationPhysiological pharmacokinetic models are derived from basic considerations of physiological, anatomical, and pharmacologic principles. These modes can simultaneously predict drug levels in blood, organs, and tissues.
Christensen, John Mark.
core  

Bleeding patterns in postmenopausal women using continuous combination hormone replacement therapy with conjugated estrogen and medroxyprogesterone acetate or with 17β-estradiol and norethindrone acetate

, 2001
OBJECTIVE: We studied bleeding patterns in postmenopausal women who were using 2 types of continuous combination regimens. STUDY DESIGN: A prospective, double-blind, randomized study of 208 postmenopausal women treated with conjugated estrogen, 0.625 mg,
Torbjörn Bäckström, Jonsson, Björn,, Ödmark, Inga-Stina,, Björn Jonsson, Bäckström, Torbjörn,, Inga-Stina Ödmark   +5 more
core   +1 more source

Dydrogesterone and Letrozole Combination for the Treatment of Endometriosis: A Mechanism‐Based Therapeutic Approach

Obstetrics and Gynecology International, Volume 2026, Issue 1, 2026.
Endometriosis is a complex, estrogen‐dependent disease with limited effective treatments that often focus on symptom management rather than addressing the underlying pathology. Current therapies, such as progestins and GnRH agonists, have significant side effects (weight gain, mood changes, decreased bone mineral density, and menopausal symptoms) and ...
Santosh Kumar Rai, Rakesh Kumar, Mohd Imran Khan, Anil Kumar, Manvinder Singh   +4 more
wiley   +1 more source

Uterine “twisting sign”: A new potential ultrasonographic soft marker for deep endometriosis

International Journal of Gynecology &Obstetrics, Volume 171, Issue 3, Page 1355-1363, December 2025.
Abstract Objective The objective of the current study was to evaluate the “twisting sign,” defined as uterine fundus rotation observed on transvaginal sonography (TVS), as a potential soft marker for deep endometriosis (DE) and its association with specific DE localizations and indirect signs.
Fabio Barra, Simone Ferrero, Umberto Perrone, Giulio Evangelisti, Alessandra Pulliero, Alberto Izzotti, Umberto Leone Roberti Maggiore, Stefano Bogliolo   +7 more
wiley   +1 more source

The Management of Heavy Menstrual Bleeding After Percutaneous Coronary Intervention in a Woman of Reproductive Age

Frontiers in Pharmacology, 2019
Heavy menstrual bleeding (HMB), previously known as menorrhagia, is in place with heavy flow and longer lasting days of bleeding during menstrual period, sequentially leading to anemia.
Zhi-Chun Gu, Fang-Hong Shi, Jie Zhu, Fang Wan, Long Shen, Hao Li   +5 more
doaj   +1 more source

Establishing a Quantitative Framework for Combined Oral Contraceptives: Evaluating the Impact of Drug–Drug Interactions on Exposure and Clinical (Surrogate) Efficacy Endpoints

The Journal of Clinical Pharmacology, Volume 65, Issue 12, Page 1855-1863, December 2025.
Abstract According to the FDA Guidance for Industry on Clinical Drug Interaction (DDI) Studies with Combined Oral Contraceptives (COCs), sponsors are expected to conduct dedicated clinical DDI studies if in vitro findings suggest weak or moderate CYP3A induction, while concomitant use of COCs with strong inducers should be avoided. The guidance further
Dain Chun, Huili Chen, Brian Cicali, Serge Guzy, Joachim Hoechel, Tianze Jiao, Valvanera Vozmediano, Stephan Schmidt   +7 more
wiley   +1 more source

Microbial and Metabolomic Variations Correlated With Gastric Cancer Subtypes and Prognosis

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Multi‐omics analysis of 50 GC patients revealed conserved microbial‐metabolite signatures across Lauren/ZJU subtypes, with ZJU‐specific features—Eubacterium_ventriosum_group and N6‐Succinyl Adenosine—enabling superior prognostic stratification. ABSTRACT Gastric cancer (GC) persists as the third most prevalent malignancy in China.
Yan Yang, Liping Wen, Wu Lin, Yiran Chen, Rui Yang, Chao He, Yingzi Zhang, Jing Zhang, Haohao Wang, Haiyong Wang, Lisong Teng   +10 more
wiley   +1 more source

Effects of oral, continuous and transdermal cyclic 17-? estradiol and norethindrone acetate replacement therapy on platelet aggregation in postmenopausal women

, 2002
OBJECTIVE: To evaluate the affects of an oral continuous and transdermal cyclic 17-beta estradiol and norethindrone acetate combination on platelet aggregation in postmenopausal women.
Yüce, MA, Yardim, T, Kaplan, PB, Sayin, NC, Gücer, F   +4 more
core   +1 more source

Effects of chronic mestranol and (or) norethindrone treatment on ethanol-associated decreases in hepatic benzo[a]pyrene hydroxylase activity and increases in central vein fat accumulation in the female Wistar rat

, 1983
Wistar rats were fed a liquid diet, Sustacal®, which contained ethanol (40% of calories) or isocaloric sucrose. Mestranol and norethindrone in pharmacological doses were also administered via this diet. Hepatic microsomal benzo[a]pyrene (BP) hydroxylase,
G. D. Bellward, B. L. Warren
core   +1 more source

Human progesterone receptor (PR) is illustrated in cartoon representation and bisphenol A (BPA), methylbishydroxyphenylpentene (MBP), 4-tert-octylphenol (OP), and the bound ligand norethindrone (NET) are in stick representation in different colors.

, 2015
Human progesterone receptor (PR) is illustrated in cartoon representation and bisphenol A (BPA), methylbishydroxyphenylpentene (MBP), 4-tert-octylphenol (OP), and the bound ligand norethindrone (NET) are in stick representation in different colors.
Mansour M. Assiri (797145), Mohd Rehan (198120), Ishfaq A. Sheikh (797142), Adel M. Abuzenadah (528224), Osama S. Bajouh (797143), Ghazi A. Damanhouri (528223), Mohd A. Beg (528220), Ejaz Ahmad (161617), Samera F. AlBasri (797144)   +8 more
core   +1 more source