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International Clinical Psychopharmacology, 1993
The relationship between plasma concentration, clinical outcome and side-effects was examined in 23 patients with major depressive disorder (DSM-III-R) treated with fluoxetine. All patients received a fixed dose of 20 mg for 6 weeks. Good response was observed in 57% of patients, while 30% of patients had moderate responses after 6 weeks of treatment ...
T R, Norman +4 more
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The relationship between plasma concentration, clinical outcome and side-effects was examined in 23 patients with major depressive disorder (DSM-III-R) treated with fluoxetine. All patients received a fixed dose of 20 mg for 6 weeks. Good response was observed in 57% of patients, while 30% of patients had moderate responses after 6 weeks of treatment ...
T R, Norman +4 more
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Improved HPLC determination of fluoxetine and norfluoxetine in human plasma
Chromatographia, 1999An HPLC method with fluorescence detection has been developed for the determination of fluoxetine and its main metabolite norfluoxetine in human plasma. Pretreatment of the biological samples by liquid-liquid extraction was used to improve the sensitivity of a previously published SPE procedure.
M. A. Raggi +5 more
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An asymmetric dihydroxylation route to enantiomerically pure norfluoxetine and fluoxetine
Tetrahedron Letters, 2002An efficient, practical asymmetric synthesis of (R)-norfluoxetine 1 and (R)-fluoxetine 2 has been achieved. The synthetic strategy features a Sharpless asymmetric dihydroxylation (SAD) route to the common building block 1,3-amino alcohol 9, from which (R)-norfluoxetine, (R)-fluoxetine and other related analogs can be synthesized.
Rajesh Kumar Pandey +2 more
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Asymmetric dihydroxylation route to (R)-isoprenaline, (R)-norfluoxetine and (R)-fluoxetine
Tetrahedron: Asymmetry, 2004An efficient asymmetric synthesis of enantiomerically pure (R)-isoprenaline, (R)-norfluoxetine and (R)-fluoxetine is described using Sharpless asymmetric dihydroxylation as the key step.
Pradeep Kumar +2 more
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T-Type Calcium Channels Are Inhibited by Fluoxetine and Its Metabolite Norfluoxetine
Molecular Pharmacology, 2006Fluoxetine, a widely used antidepressant that primarily acts as a selective serotonin reuptake inhibitor, also inhibits various neuronal ion channels. Using the whole-cell patch-clamp technique, we have examined the effects of fluoxetine and norfluoxetine, its major active metabolite, on cloned low-voltage-activated T-type calcium channels (T channels)
Achraf, Traboulsie +4 more
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Red cell and plasma concentrations of fluoxetine and norfluoxetine.
Veterinary and human toxicology, 1993To study the distribution of fluoxetine and norfluoxetine in blood compartments we determined their concentrations in red cells and plasma after the addition of 500 ng/ml of each compound to human blood in vitro. Red cell and plasma fluoxetine concentrations were 493 +/- 79 ng/ml and 454 +/- 53 ng/ml, respectively (P > 0.1).
Y, Amitai +4 more
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Ratio of plasma fluoxetine to norfluoxetine concentrations and associated sedation.
The Journal of clinical psychiatry, 1992Sedation is an often unanticipated but clinically significant side effect in some patients treated with fluoxetine. To date, no clinical or pharmacokinetic factors have been identified in association with sedation in fluoxetine-treated patients. We hypothesized that patients experiencing sedation might have elevated plasma concentrations of fluoxetine ...
P E, Keck, S L, McElroy
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Fluoxetine and Norfluoxetine Plasma Levels After Discontinuing Fluoxetine Therapy
Journal of Clinical Psychopharmacology, 2001D J, Brunswick +6 more
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Fluoxetine and norfluoxetine plasma levels in major depression
Biological Psychiatry, 1995J.D. Amsterdam +6 more
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