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Enantioselective quantification of fluoxetine and norfluoxetine by HPLC in wastewater effluents
Chemosphere, 2014 Microbial degradation is the most important process to remove organic pollutants in Waste Water Treatment Plants. Regarding chiral compounds this process is normally enantioselective and needs the suitable analytical methodology to follow the removal of both enantiomers in an accurate way. Thus, this paper describes the development and validation of an
Ana R Ribeiro +2 more
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Norfluoxetine Induces Spawning and Parturition in Estuarine and Freshwater Bivalves
Bulletin of Environmental Contamination and Toxicology, 2008Fluoxetine, a commonly prescribed antidepressant (Prozac), has been detected in sewage effluent. Its active metabolite norfluoxetine is more potent and has been detected in sewage influent and in fish tissues. We tested the effects of norfluoxetine on spawning and parturition in bivalves.
Peter P Fong
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Comparison of norfluoxetine enantiomers as serotonin uptake inhibitors in vivo
Neuropharmacology, 1992Norfluoxetine, the N-desmethyl metabolite of fluoxetine, has been reported to resemble fluoxetine in being a potent and selective inhibitor of the serotonin uptake carrier. The enantiomers of norfluoxetine have now been compared as serotonin uptake inhibitors in vivo, based on their antagonism of p-chloroamphetamine-induced depletion of serotonin in ...
Ray W Fuller +2 more
exaly +3 more sources
Therapeutic Drug Monitoring, 1998 A standardization of the analytical procedures for monitoring of fluoxetine and norfluoxetine enantiomers is described. Simultaneous determination of fluoxetine and norfluoxetine enantiomers in plasma and serum was performed by high-performance liquid chromatography with a chiral stationary phase, using ultraviolet absorbance detection.
ZUCCARO P +7 more
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Norfluoxetine and fluoxetine have similar anticonvulsant and Ca2+ channel blocking potencies
Brain Research Bulletin, 2005Norfluoxetine is the most important active metabolite of the widely used antidepressant fluoxetine but little is known about its pharmacological actions. In this study the anticonvulsant actions of norfluoxetine and fluoxetine were studied and compared to those of phenytoin and clonazepam in pentylenetetrazol-induced mouse epilepsy models. Pretreatment
Valeria Kecskeméti +2 more
exaly +3 more sources
Persistence of norfluoxetine in marine mussels
Marine Pollution Bulletin, 2023The concentration of pharmaceuticals in coastal waters is tending towards increasing due to a shift of the human population into coastal zones. In parallel, the number of prescriptions of antidepressants, mainly selective serotonin reuptake inhibitors (SSRI), is constantly growing.
Anna, Hallmann +6 more
openaire +2 more sources