Results 141 to 150 of about 1,322 (181)

Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine

British Journal of Pharmacology, 2005
1. Block of the human two-pore domain potassium (2-PK) channel TREK-1 by fluoxetine (Prozac) and its active metabolite, norfluoxetine, was investigated using whole-cell patch-clamp recording of currents through recombinant channels in tsA 201 cells.
Emma L Veale, Alistair Mathie
exaly   +2 more sources

Simultaneous determination of plasma levels of fluvoxamine and of the enantiomers of fluoxetine and norfluoxetine by gas chromatography-mass spectrometry

Biomedical Applications, 1996
A gas chromatographic-mass spectrometric method is presented which allows the simultaneous determination of the plasma concentrations of fluvoxamine and of the enantiomers of fluoxetine and norfluoxetine after derivatization with the chiral reagent, (S)-(
Chin B Eap, P Baumann
exaly   +2 more sources

Hollow‐fibre supported liquid membrane extraction for determination of fluoxetine and norfluoxetine concentration at ultra trace level in sewage samples

Journal of Separation Science, 2007
In this study, a method was developed for determining the concentration of the pharmaceutical fluoxetine and its metabolite, norfluoxetine, in sewage water samples.
Saioa Zoriţa, Lennart Mårtensson, Lennart Mathiasson   +2 more
exaly   +2 more sources

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Pharmacokinetics of fluoxetine and norfluoxetine in pregnancy and lactation

Clinical Pharmacology & Therapeutics, 2003
The aim of this prospective clinical trial was to investigate the pharmacokinetics of fluoxetine and its active metabolite, norfluoxetine, during pregnancy, delivery, and lactation in mothers and their infants.Eleven mothers taking fluoxetine and their infants were enrolled in the study.
Tuija, Heikkinen, Ulla, Ekblad, Pertti, Palo, Kari, Laine   +3 more
openaire   +2 more sources

Fluoxetine/Norfluoxetine Concentrations in Human Milk

Pediatrics, 1992
Drug therapy for mothers with postpartum depression is complicated by the need to consider the effect of drugs taken by the mother on the nursing infant. In many cases abrupt weaning of the infant is prescribed so that drug therapy may begin, but this may precipitate conflicting feelings of guilt and cause hormonal upset in the mother, both of which ...
K J, Burch, B G, Wells
openaire   +2 more sources

Serum Fluoxetine and Norfluoxetine Concentrations and Antidepressant Response

Therapeutic Drug Monitoring, 1989
A high-performance liquid chromatography assay for fluoxetine and its major metabolite, norfluoxetine, was established. Serum concentrations of the two were measured in 13 depressed outpatients following a 6-week trial of the drug. No significant correlations were obvious between clinical improvement as measured by the Hamilton Rating Scale for ...
M W, Kelly, P J, Perry, S G, Holstad, M J, Garvey   +3 more
openaire   +2 more sources

Determination of fluoxetine and norfluoxetine by high-performance liquid chromatography

Journal of Chromatography A, 1990
A high-performance liquid chromatographic assay was developed for a recently introduced atypical antidepressant, fluoxetine and its demethylated metabolite, norfluoxetine. Prior to analysis, aliquots of alkalinized plasma were extracted with n-hexane and isoamyl alcohol, followed by back-extraction with diluted phosphoric acid.
S H, Wong, S S, Dellafera, R, Fernandes, H, Kranzler   +3 more
openaire   +2 more sources

Trace analysis of fluoxetine and its metabolite norfluoxetine. Part II: Enantioselective quantification and studies of matrix effects in raw and treated wastewater by solid phase extraction and liquid chromatography–tandem mass spectrometry

Journal of Chromatography A, 2012
The isotope-labeled compounds fluoxetine-d5 and norfluoxetine-d5 were used to study matrix effects caused by co-eluting compounds originating from raw and treated wastewater samples, collected in Uppsala, Sweden.
Barclay, Victoria K H,, Tyrefors, Niklas L,, Johansson, I Monika,, Pettersson, Curt E,   +3 more
exaly   +2 more sources

Fluoxetine and norfluoxetine plasma concentrations during relapse-prevention treatment

Journal of Affective Disorders, 2002
Virtually no attention has been given to the relationship between antidepressant plasma drug concentrations and relapse-prevention during maintenance therapy. The purpose of this study was to investigate the relationship between steady-state plasma drug concentrations and outcome during relapse-prevention therapy with fluoxetine.The patients studied ...
David J, Brunswick, Jay D, Amsterdam, Jan, Fawcett, Frederic M, Quitkin, Frederick W, Reimherr, Jerrold F, Rosenbaum, Charles M, Beasley   +6 more
openaire   +2 more sources

Determination of Fluoxetine and Norfluoxetine Concentrations in Cadaveric Allograft Skin

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1998
Fluoxetine hydrochloride is the sixth most prescribed drug in the United States and is administered to treat major depression. A cadaveric skin donation was obtained from a 46‐year‐old woman who died as a result of a fluoxetine overdose. Due to the potential penetration of the drug and its major metabolite, norfluoxetine, into skin, the safety of using
Neudeck, Brien L., Taddonio, Thomas E., Garner, Warren L., Welage, Lynda S.   +3 more
openaire   +3 more sources