A review of recommendations, efficacy, and patient safety for over-the-counter norgestrel for daily contraception [PDF]
Exploratory Research in Clinical and Social PharmacyPurpose: This narrative review examines the implications of norgestrel, a progestin-only oral contraceptive, becoming newly available over-the-counter (OTC) in the United States.
Gia Tran +5 more
doaj +3 more sources
The synthetic progestin norgestrel modulates Nrf2 signaling and acts as an antioxidant in a model of retinal degeneration [PDF]
Redox Biology, 2016 Retinitis pigmentosa (RP) is one of the most common retinal degenerative conditions affecting people worldwide, and is currently incurable. It is characterized by the progressive loss of photoreceptors, in which the death of rod cells leads to the ...
Thomas Cotter, Sarah L Roche
exaly +4 more sources
Progesterone Attenuates Microglial-Driven Retinal Degeneration and Stimulates Protective Fractalkine-CX3CR1 Signaling. [PDF]
PLoS ONE, 2016 Retinitis pigmentosa (RP) is a degenerative disease leading to photoreceptor cell loss. Mouse models of RP, such as the rd10 mouse (B6.CXBl-Pde6brd10/J), have enhanced our understanding of the disease, allowing for development of potential therapeutics ...
Sarah L Roche +7 more
doaj +3 more sources
A multi-stage computational pipeline for repurposing FDA-approved drugs: application to EGFR C797S–mutant NSCLC [PDF]
Frontiers in ChemistryBackground/ObjectivesNon-small cell lung cancer (NSCLC) is a leading cause of cancer-related death globally. Resistance to third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, particularly due to the C797S mutation, poses ...
Mansour S. Alturki +11 more
doaj +2 more sources
Progestogen use and the risk of intracranial meningioma: a systematic review and meta-analysisResearch in context [PDF]
EClinicalMedicineSummary: Background: Meningiomas are the most common primary brain tumours in adults. Concerns have emerged about a possible link between progestogen use and intracranial meningioma; we assessed this association.
Benoit Hudelist +12 more
doaj +2 more sources
JMIR Research Protocols, 2021 BackgroundProgestin-only contraceptive pills (POP) are commonly reserved for women with medical comorbidities but in actuality, POPs can be safely used by anyone wanting to prevent pregnancy.
Edelman, Alison +5 more
doaj +1 more source
SYNTHESIS OF SOME POTENTIAL ANTIESTROGENIC AGENTS [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2005 Some novel steroidal arylidene derivatives were synthesized and representative examples were tested for their antiestrogenic activity. The active compounds were subjected for antitumor activity screening.
Gehan Hegazy +2 more
doaj +1 more source
Food Chemistry: X, 2022 A simple and rapid method based on miniaturized solid-phase microextraction (mini-SPME) followed by gas chromatography–mass spectrometry was developed to identify eight endocrine disruptors (atrazine, diethylstilbestrol, hexestrol, estrone, estradiol ...
Mereke Alimzhanova +4 more
doaj +1 more source
Pharmacology Research & Perspectives, 2022 Compounds that induce 5‐aminolevulinic acid [ALA] synthase‐1 and/or cytochromes P‐450 may induce acute porphyric attacks in patients with the acute hepatic porphyrias [AHPs].
Christopher D. Ma +4 more
doaj +1 more source
Estudio clínico comparativo de dos diferentes progestágenos administrados en implantes subdérmicos
Ciencia y Sociedad, 1978 Este estudio muestra que las cápsulas de silastic contienen dos progestágenos diferentes, etil-norges-trienona y d-norgestrel, fueron colocadas en la región ventral del brazo subdominante de 100 mujeres, para fines anticonceptivos, en un estudio doble ...
Francisco Álvarez Sánchez +3 more
doaj +1 more source