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Vulnerability of long-range inputome of basal forebrain in normal aging mice [PDF]

Frontiers in Aging Neuroscience
IntroductionAs the human undergoes the process of aging, it becomes evident that the elderly population exhibits age-related cognitive decline. The basal forebrain (BF) has been shown to have complex connections with the hippocampus (Hip) and medial ...
Tingting Sun, Jiale Chen, Bimin Liu, Anan Li, Hui Gong, Xiangning Li, Xiangning Li   +6 more
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Normal Aging Induces Changes in the Brain and Neurodegeneration Progress: Review of the Structural, Biochemical, Metabolic, Cellular, and Molecular Changes

Frontiers in Aging Neuroscience, 2022
Aging is accompanied by many changes in brain and contributes to progressive cognitive decline. In contrast to pathological changes in brain, normal aging brain changes have relatively mild but important changes in structural, biochemical and molecular ...
Jiseon Lee, Hee-Jin Kim
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Longitudinal changes in hand dominance and manual dexterity in normal aging and mild cognitive impairment (MCI): a kinematic study [PDF]

Frontiers in Aging Neuroscience
IntroductionDecrements on hand dominance in older populations, including neurodegenerative conditions, have been reported cross-sectionally. At present, no longitudinal research on this issue is available.MethodsTo address this research gap, we conducted
Olena Vasylenko, Claudia Rodríguez-Aranda   +1 more
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Multimodal magnetic resonance imaging reveals distinct sensitivity of hippocampal subfields in asymptomatic stage of Alzheimer’s disease

Frontiers in Aging Neuroscience, 2022
While hippocampal atrophy and its regional susceptibility to Alzheimer’s disease (AD) are well reported at late stages of AD, studies of the asymptomatic stage of AD are limited but could elucidate early stage pathophysiology as well as provide ...
Junjie Wu, Syed S. Shahid, Syed S. Shahid, Qixiang Lin, Antoine Hone-Blanchet, Antoine Hone-Blanchet, Jeremy L. Smith, Benjamin B. Risk, Aditya S. Bisht, David W. Loring, Felicia C. Goldstein, Allan I. Levey, James J. Lah, Deqiang Qiu, Deqiang Qiu   +14 more
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Sleep in Normal Aging, Homeostatic and Circadian Regulation and Vulnerability to Sleep Deprivation

Brain Sciences, 2021
In the context of geriatric research, a growing body of evidence links normal age-related changes in sleep with many adverse health outcomes, especially a decline in cognition in older adults.
Jacques Taillard, Claude Gronfier, Stéphanie Bioulac, Pierre Philip, Patricia Sagaspe   +4 more
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Modification of Cycle Life Model for Normal Aging Trajectory Prediction of Lithium-Ion Batteries at Different Temperatures and Discharge Current Rates

World Electric Vehicle Journal, 2022
Battery life is of critical importance for the reliable and economical operation of electric vehicles (EVs). Normal aging accounts for more than 80% of the battery available cycle range.
Xinyu Jia, Caiping Zhang, Leyi Wang, Weige Zhang, Linjing Zhang   +4 more
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Gene Expression Microarray Data Meta-Analysis Identifies Candidate Genes and Molecular Mechanism Associated with Clear Cell Renal Cell Carcinoma

Cell Journal, 2020
Objective: We aimed to explore potential molecular mechanisms of clear cell renal cell carcinoma (ccRCC) and provide candidate target genes for ccRCC gene therapy. Material and Methods: This is a bioinformatics-based study.
Ying Wang, Haibin Wei, Lizhi Song, Lu Xu, Jingyao Bao, Jiang Liu   +5 more
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Age-Related Decline in Brain Myelination: Quantitative Macromolecular Proton Fraction Mapping, T2-FLAIR Hyperintensity Volume, and Anti-Myelin Antibodies Seven Years Apart

Biomedicines, 2023
Age-related myelination decrease is considered one of the likely mechanisms of cognitive decline. The present preliminary study is based on the longitudinal assessment of global and regional myelination of the normal adult human brain using fast ...
Marina Khodanovich, Mikhail Svetlik, Anna Naumova, Daria Kamaeva, Anna Usova, Marina Kudabaeva, Tatyana Anan’ina, Irina Wasserlauf, Valentina Pashkevich, Marina Moshkina, Victoria Obukhovskaya, Nadezhda Kataeva, Anastasia Levina, Yana Tumentceva, Vasily Yarnykh   +14 more
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Individual prediction of hemispheric similarity of functional connectivity during normal aging

Frontiers in Psychiatry, 2022
In the aging process of normal people, the functional activity pattern of brain is in constant change, and the change of brain runs through the whole life cycle, which plays a crucial role in the track of individual development.
Yingteng Zhang
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A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability

Nature Communications, 2017
DDRGK1 is an ER membrane protein that is subject to Ufm1 modification, but its function in ER homeostasis is unknown. Here, the authors show that ufmylated DDRGK1 interacts with and stabilizes the ER-stress sensor protein IRE1a, in turn repressing ER ...
Jiang Liu, Ying Wang, Lizhi Song, Linghua Zeng, Weiwei Yi, Ting Liu, Huanzhen Chen, Miao Wang, Zhenyu Ju, Yu-Sheng Cong   +9 more
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