Results 101 to 110 of about 6,131,287 (277)

On a Logistic Approximation to the Normal and Other Cumulative Distribution Functions

open access: yesRecoletos Multidisciplinary Research Journal, 2014
This paper proposes an approach that maintains the simplicity of various approximations as well as having a closed- form algebraic inverse yet easily generalizable to the approximation of other cumulative distribution functions.
Roberto N. Padua   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Reliability Assessment for Small-Sample Accelerated Life Tests with Normal Distribution

open access: yesMachines
A significant challenge in the accelerated life test (ALT) is the reliance on large sample sizes and multiple stress levels, which results in high costs and long test durations.
Jianchao Guo, Huimin Fu
doaj   +1 more source

Evaluating the Normal Distribution [PDF]

open access: yes
This article provides a little table-free C function that evaluates the normal distribution with absolute error less than 8 x 10 ^-16 . A small extension provides relative error near the limit available in double precision: 14 to 16 digits, the limits ...
George Marsaglia
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Analysis and assessment of the validity dough "theory of functions of the complex variable"

open access: yesВестник Самарского государственного технического университета. Серия: Психолого-педагогические науки, 2017
In article the analysis of quality of the "Theory of Functions of a Complex Variable" test is carried out. The dough validity in normal way to distribution, according to the contents, on the distinguishing ability is estimated.
Lidiya A. Muratova
doaj  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

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