Results 111 to 120 of about 2,404,671 (311)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
The Exact Cumulative Distribution Function of a Ratio of Quadratic Forms in Normal Variables with Application to the AR(1) Model. [PDF]
Often neither the exact density nor the exact cumulative distribution function (CDF) of a statistic of interest are available in the statistics and econometrics literature (for example the maximum likelihood estimator of the autocorrelation coefficient ...
Giovanni Forchini
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Skew normal distribution [PDF]
, 2021 Title: Skew normal distribution Author: František Helebrand Department: Department of Probability and Mathematical Statistics Supervisor: RNDr. Šárka Hudecová, Ph.D., Department of probability and mathematical statistics Abstract: In this paper, the ...
Helebrand, František
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
On Bayesian inference with conjugate priors for scale mixtures of normal distributions
, 2010 Bayesian inference is considered for the multivariate regression model with distribution of the random responses belonging to the multivariate scale mixtures of normal distributions.
Ng, V.M.
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Oscillating neural circuits: Phase, amplitude, and the complex normal distribution. [PDF]
Can J Stat, 2023 Urban KN, Bong H, Orellana J, Kass RE.
europepmc +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A Note On Skew-Normal Distribution Approximation To The Negative Binomal Distribution
, 2011 This article revisits the problem of approximating the negative binomial distribution. Its goal is to show that the skew-normal distribution, another alternative methodology, provides a much better approximation to negative binomial probabilities than ...
Lin, Jyh-Jiuan; Chang, Ching-Hui; Jou, Rosemary +1 more
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clrDV: a differential variability test for RNA-Seq data based on the skew-normal distribution. [PDF]
PeerJ, 2023 Li H, Khang TF.
europepmc +1 more source