Results 131 to 140 of about 576,763 (311)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
, 2004 Rasjedi su osnovne strukturne jedinice litosfere. Nastaju pucanjem i pomicanjem dijelova stijenske mase pod utjecajem sila gravitacije, ekspanzije ili kompresije.
Ema Jurkin, Jasna Kos-Modor
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
, 2005 Numerous proposed and developed superconducting fault current limiters and self-limiting transformers limit successfully fault currents but do not provide uninterrupted supplying of consumers. A design investigated in the work combines the functions of a
Altov +18 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Applied SciencesEarthquake environmental effects may significantly contribute to the damage caused by seismic events; similar to ground motion, the environmental effects are globally stronger in the vicinity and decrease moving away from the epicenter or seismogenic ...
Marco Pizza +5 more
doaj +1 more source
Practical Model-Based Diagnosis with Qualitative Possibilistic Uncertainty [PDF]
, 2013 An approach to fault isolation that exploits vastly incomplete models is presented. It relies on separate descriptions of each component behavior, together with the links between them, which enables focusing of the reasoning to the relevant part of the ...
Cayrac, Didier +2 more
core
, 2017 Presented as part of the Geological Society of American (GSA) Distinguished Lecturer Tour 2017.How Do Normal Faults Grow?Normal faults grow via a sympathetic increase in their displacement and length (‘isolated model’), or by rapid establishment of their near-final length prior to significant displacement accumulation (‘constant-length model’).
openaire +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source