Results 51 to 60 of about 576,763 (311)

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Geomorphology of the Gubbio Basin (Central Italy): understanding the active tectonics and earthquake potential

open access: yesAnnals of Geophysics, 2003
The Gubbio Basin is a 22 km long, 4 km wide depression located within the North-Central Apennines fold-andthrust belt. The basin is bounded to the east by the Gubbio Fault, a W-dipping, normal fault dissecting a large Jurassic-Oligocene ...
G. Valensise   +3 more
doaj   +1 more source

The Use of Interferometric Synthetic Aperture Radar for Isolating the Contribution of Major Shocks: The Case of the March 2021 Thessaly, Greece, Seismic Sequence

open access: yesGeosciences, 2021
We study the surface deformation following a moderate size M5+ earthquake sequence that occurred close to Tyrnavos village (Thessaly, Greece) in March 2021.
Cristiano Tolomei   +5 more
doaj   +1 more source

Structural heterogeneity and permeability in faulted eolian sandstone: Implications for subsurface modeling of faults [PDF]

open access: yes, 2002
We determined the structure and permeability variations of a 4 km-long normal fault by integrating surface mapping with data from five boreholes drilled through the fault (borehole to tens of meters scale).
Evans, J.P.   +4 more
core  

Fault Analysis to Determine Deformation History of Kubang Pasu Formation at South of UniMAP Stadium Hill, Ulu Pauh, Perlis, Malaysia [PDF]

open access: yes, 2016
The Kubang Pasu Formation at South of UniMap Stadium Hill has suffered deformation that produced fault with various types and orientations. First deformation (ST1) is southeast – northwest were resulted normal, reverse, dextral and sinistral fault.
Suryadi, A. (Adi)
core   +3 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

The influence of normal stress and sliding velocity on the frictional behaviour of calcite at room temperature. Insights from laboratory experiments and microstructural observations [PDF]

open access: yes, 2016
The presence of calcite in and near faults, as the dominant material, cement, or vein fill, indicates that the mechanical behaviour of carbonate-dominated material likely plays an important role in shallow- and mid-crustal faulting. To better understand
Carpenter, B. M   +3 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Difference and mechanism of dynamic behaviors between two walls of normal fault

open access: yesMeitan kexue jishu, 2023
With the development of large-scale mining activities, the normal fault is prone to slide and instability, resulting in vibration waves, which show significant asymmetric dynamic response characteristics in the areas on both sides of the fault.
TAN Yunliang   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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