Results 91 to 100 of about 7,316,719 (298)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Poincaré Normal and Renormalized Forms

open access: yesActa Applicandae Mathematica, 2002
standard LaTeX, 20 ...
openaire   +2 more sources

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Normal Forms in Combinatory Logic

open access: yesNotre Dame Journal of Formal Logic, 1994
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Comparison of metaheuristics for obtaining fuzzy predicates: a curious case

open access: yesRevista Cubana de Ciencias Informáticas, 2014
This paper presents a comparative study of three metaheuristics on the problem of obtaining fuzzy predicates with high truth value. According to the No Free Lunch Theorem (NFL) cannot establish any general superiority of ...
Taymi Ceruto-Cordovés   +3 more
doaj  

On the Modularity of Normal Forms in Rewriting

open access: yesJournal of Symbolic Computation, 1996
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

What the Oregon Normal School has done toward the preparation of rural teachers

open access: yes, 1918
"This bulletin will try to answer four questions: 1. What has the Oregon Normal done toward the preparation of rural teachers? 2. What is it doing now? 3. What should it do? 4. How can it do it?"--Page 2.[prepared by M.S.

core  

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

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