Results 31 to 40 of about 159,573 (229)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Deep Learning for Bifurcation Detection: Extending Early Warning Signals to Dynamical Systems with Coloured Noise

Mathematics
Deep learning models have demonstrated remarkable success in recognising tipping points and providing early warning signals. However, there has been limited exploration of their application to dynamical systems governed by coloured noise, which ...
Yazdan Babazadeh Maghsoodlo, Daniel Dylewsky, Madhur Anand, Chris T. Bauch   +3 more
doaj   +1 more source

The Fermi-Pasta-Ulam problem: 50 years of progress

, 2005
A brief review of the Fermi-Pasta-Ulam (FPU) paradox is given, together with its suggested resolutions and its relation to other physical problems. We focus on the ideas and concepts that have become the core of modern nonlinear mechanics, in their ...
Arnold V. I., Arnold V. I., Arnold V. I., Benettin G., Berezin Yu. A., Berezin Yu. A., Berman G. P., Berman G. P., Berman G. P., Chirikov B. V., Dodd R. K., Fermi E., Izrailev F. M., Izrailev F. M., Izrailev F. M., Kolmogorov A. N., Kryloff N., Krylov N. S., Moser J., Nishida T., Pitaevskii L. P., Prigogine I., Sagdeev R. Z., Ulam S. M., Zabusky N. J.   +24 more
core   +1 more source

Computation of the Unique Normal Form for Nonlinear Dynamical Systems in the Mechanical Applications

DEStech Transactions on Engineering and Technology Research, 2017
In the mechanical applications, research for degenerate bifurcations is usually connected with the normal form theory of nonlinear dynamical systems. In this paper, we mainly concern with the unique normal form for a class of three dimensional vector fields by the method of transformation with parameters. With the aid of the Maple software, a recursive
Li-ying KOU, Jing LI, Jian-pan FENG
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Dynamical laws of superenergy in General Relativity

, 2007
The Bel and Bel-Robinson tensors were introduced nearly fifty years ago in an attempt to generalize to gravitation the energy-momentum tensor of electromagnetism.
Alfonso García-Parrado Gómez-Lobo, Anderson A, Bel L, Bel L, Bel L, Bel L, Bergqvist G, Bergqvist G, Bergqvist G, Chevreton M, Ellis G F R, Eriksson I, Eriksson I, Hawking S W, Herrera L, Herrera L, Jackson D, Klainerman S, Lazkoz R, Maartens R, Martín-García J M, Mashoon B, Naber G L, Penrose R, Penrose R Rindler W, Senovilla J M M, Senovilla J M M, Stephani H, Szabados L, Thorne K S   +29 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source