Results 51 to 60 of about 88,663,689 (260)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 1988 This volume contains original research papers on topics central to Dynamical Systems, such as fractional dimensions (Hausdorff dimension, limity capacity) and limit cycles of polynomial vector fields concerning the well-known Dulac and Hilbert's 16th ...
Labarca, Rafael +2 more
core +1 more source
Observer Design for Nonlinear Dynamical Systems: Differential geometric methods
, 2021 International audienceThis book presents a differential geometric method for designing nonlinear observers for multiple types of nonlinear systems, including single and multiple outputs, fully and partially observable systems, and regular and singular ...
Boutat, Driss +3 more
core +1 more source
Normal forms of Hopf Singularities: Focus Values Along with some Applications in Physics
پژوهشهای ریاضی, 2018 This paper aims to introduce the original ideas of normal form theory and bifurcation analysis and control of small amplitude limit cycles in a non-technical terms so that it would be comprehensible to wide ranges of Persian speaking engineers and ...
Majid Gazor, Nasrin Sadri
doaj
Piecewise smooth dynamical systems: Persistence of periodic solutions and normal forms
Journal of Differential Equations, 2016 We consider an n-dimensional piecewise smooth vector field with two zones separated by a hyperplane \Sigma which admits an invariant hyperplane \Omega transversal to \Sigma containing a period annulus A fulfilled by crossing periodic solutions. For small discontinuous perturbations of these systems we develop a Melnikov-like function to control the ...
Gouveia, Marcio +3 more
openaire +5 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
, 2020 Code to numerically integrate a model for neural population dynamics in birdsong ...
dynamical-systems-laboratory-ar
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source