Results 51 to 60 of about 159,573 (229)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Dimension increase and splitting for Poincare'-Dulac normal forms

, 2005
Integration of nonlinear dynamical systems is usually seen as associated to a symmetry reduction, e.g. via momentum map. In Lax integrable systems, as pointed out by Kazhdan, Kostant and Sternberg in discussing the Calogero system, one proceeds in the ...
Gaeta, G., Walcher, S.
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Nonuniform Dichotomy Spectrum and Normal Forms for Nonautonomous Differential Systems [PDF]

, 2014
The aim of this paper is to study the normal forms of nonautonomous differential systems. For doing so, we first investigate the nonuniform dichotomy spectrum of the linear evolution operators that admit a nonuniform exponential dichotomy, where the ...
Zhang, Xiang
core  

Non-holonomy, critical manifolds and stability in constrained Hamiltonian systems

, 1999
We approach the analysis of dynamical and geometrical properties of nonholonomic mechanical systems from the discussion of a more general class of auxiliary constrained Hamiltonian systems.
Chen, Thomas
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The stellar and sub-stellar IMF of simple and composite populations

, 2012
The current knowledge on the stellar IMF is documented. It appears to become top-heavy when the star-formation rate density surpasses about 0.1Msun/(yr pc^3) on a pc scale and it may become increasingly bottom-heavy with increasing metallicity and in ...
A Duquennoy, A Maeder, A Parravano, A Sollima, A Sollima, A Stolte, A Vazdekis, A Vazdekis, AA Muench, AE Piskunov, AJ Cenarro, AN Belikov, AP Whitworth, AR Boss, AS Eddington, AT Myers, B Binggeli, B García, B Reipurth, BG Elmegreen, BG Elmegreen, BG Elmegreen, BG Elmegreen, BG Elmegreen, BG Elmegreen, BG Elmegreen, BG Elmegreen, BG Elmegreen, C Briceño, C Esteban, C Flynn, C Grillo, C Hayashi, C Koen, C Low, C Reylé, C Soubiran, C Weidner, C Weidner, C Weidner, C Weidner, C Weidner, C Weidner, C Weidner, C Yasui, CA Tout, CJ Clarke, CJ Grillmair, CJ Lada, CJ Lonsdale, CL Slesnick, CM Baugh, CM Boily, D Calzetti, D Gouliermis, D Gouliermis, D Stamatellos, D Stamatellos, D Stamatellos, D Stamatellos, D Vanbeveren, DA Fischer, DA Forbes, DA Tilley, DA Tilley, DC Heggie, DF Figer, DJ Pinfield, DJ Price, DR Weisz, E Brocato, E Casuso, E Corbelli, E Moraux, E Schilbach, E Vesperini, E Vesperini, EA Evstigneeva, EA Hoversten, EE Salpeter, F D’Antona, F Egusa, F Motte, F Najarro, F Palla, F Paresce, F Selman, FC Adams, FC Adams, FD Kahn, G Basri, G Bosch, G Chabrier, G Chabrier, G Chabrier, G Chabrier, G Chabrier, G Chabrier, G Duchêne, G Garcia-Segura, G Garcia-Segura, G Marchi de, G Marchi de, G Marchi De, G Piotto, G Weigelt, G Wuchterl, G Wuchterl, GE Miller, GR Blumenthal, GR Meurer, H Bartko, H Baumgardt, H Baumgardt, H Bouy, H Jahreiss, H Kirk, H Sana, H Zinnecker, H Zinnecker, HT Janka, I Baraffe, I Misgeld, I Thies, I Thies, I Thies, I Thies, IA Bonnell, IA Bonnell, IA Bonnell, IA Bonnell, IA Bonnell, IA Bonnell, IN Reid, IN Reid, IN Reid, IN Reid, J Binney, J Bouvier, J Dabringhausen, J Dabringhausen, J Dabringhausen, J Jijina, J Köppen, J Maíz Apellániz, J Maíz Apellániz, J Maíz Apellániz, J Pflamm-Altenburg, J Pflamm-Altenburg, J Pflamm-Altenburg, J Pflamm-Altenburg, J Pflamm-Altenburg, J Pflamm-Altenburg, J Pflamm-Altenburg, J Pflamm-Altenburg, J Strader, JB Lamb, JC Tan, JD Neill, JE Dale, JE Gizis, JH Jeans, JJ Bochanski, JL Beuzit, JL Halbwachs, JM Kirk, JM Oliveira, JM Scalo, JN Bahcall, JP Anderson, JS Kalirai, JS Ulvestad, K Fuhrmann, K Kuijken, KD Finkelstein, KL Luhman, KL Luhman, KS Boer de, L Siess, L Testi, LA Hillenbrand, LA Hillenbrand, LJ Smith, LM Close, LR Penny, M Andersen, M Andersen, M Beech, M Dominik, M Fellhauer, M Fellhauer, M Fellhauer, M Fellhauer, M Fumagalli, M Haywood, M Mac Low, M Marks, M Marks, M Marks, M Marks, M Marks, M Marks, M Nagashima, M Ramspeck, M Schmalzl, M Schwarzschild, M Sirianni, MA Pérez-Torres, MG Wolfire, MJ Disney, MN Machida, MN Machida, MR Bate, MR Bate, MR Bate, MR Krumholz, MR Krumholz, MR Krumholz, MS Oey, MS Oey, N Bastian, N Ivanova, N Kevlahan, N Lodieu, N McCrady, N Moeckel, N Murray, N Phan-Bao, N Reid, N Rio Da, NC Hambly, NC Hambly, O Malkov, OY Malkov, P Girichidis, P Hennebelle, P Hennebelle, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Massey, P Massey, P Padoan, P Padoan, P Wang, PA Crowther, PC Clark, PC Myers, PFL Maxted, PG Dokkum van, PG Dokkum van, PJE Peebles, PP Papadopoulos, PP Papadopoulos, PR Allen, R Chini, R Fuente Marcos de La, R Kudritzki, R Parra, R Wojtak, R Wünsch, RB Larson, RB Larson, RB Stothers, RC Kennicutt Jr, RJ Parker, RJ Parker, RJ Parker, RJ Smith, RJ White, RS Klessen, RS Klessen, RS Stobie, S Banerjee, S Basu, S Basu, S Bontemps, S Dib, S Dib, S Djorgovski, S Feltzing, S Hocuk, S Mieske, S Mieske, S Nayakshin, S Recchi, S Roychowdhury, S Röser, S Shen, S Zucker, SD Murray, SF Portegies Zwart, SJ Aarseth, SLW McMillan, SM Wilkins, SP Goodwin, SP Goodwin, SP Goodwin, SP Goodwin, SP Goodwin, SS Kim, SS Vogt, ST Megeath, T Chlebowski, T Hippel von, T Maschberger, T Maschberger, T Maschberger, T Onishi, T Peters, T Peters, T Preibisch, T Tsujimoto, TE Lutz, TJ Henry, TV Veltchev, U Löckmann, V Bromm, V Joergens, V Weidemann, VV Gvaramadze, VV Gvaramadze, W Jao, W-H Hsu, WJ Wit de, WJ Wit de, X Delfosse, X Delfosse, Y Li, Z-Y Li, Å Nordlund   +344 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source