Results 71 to 80 of about 88,663,689 (260)
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
, 2023 Normal Form Theory helps to simplify linear and nonlinear dynamical systems by reducing the number of terms in the equations and by introducing a symmetry in the system.
Steindl, Alois; orcid:
core +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Computer algebra derives normal forms of stochastic differential equations [PDF]
, 2007 [Abstract]: Modelling stochastic systems has many important applications. Normal form coordinate transforms are a powerful way to untangle interesting long term dynamics from undesirably detailed microscale dynamics.
Roberts, A. J.
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How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Time-Dependent Dynamical Systems and Geophysical Flows [PDF]
, 2003 This thesis presents a dynamical systems approach to transport and mixing in geophysical flows. First, new algorithms are developed that allow one to study a dynamical system that is described in a variety of ways such as by means of observational data ...
Lekien, Francois Paul
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Birkhoff sum fluctuations in substitution dynamical systems
, 2017 We consider the deviation of Birkhoff sums along fixed orbits of substitution dynamical systems. We show distributional convergence for the Birkhoff sums of eigen functions of the substitution matrix.
Elliot Paquette +2 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
To Prof. Floris Takens, who is doing so many things
, 2008 Dynamical systems play an important role in understanding many problems in science. The variety of difficulties that they present to the dynamicist is huge.
For The Dynamical Systems
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