Results 71 to 80 of about 84,144,549 (259)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Preimage entropy for random dynamical systems

, 2007
In [6]. Cheng and Newhouse introduced and studied the new invariants - preimage entropies for deterministic dynamical systems. In this paper, the analogous notions, measure-theoretic preimage entropy and topological preimage entropy, are formulated for ...
Zhu, Yujun
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A normal form for spider diagrams of order [PDF]

, 2014
We develop a reasoning system for an Euler diagram based visual logic, called spider diagrams of order. We de- fine a normal form for spider diagrams of order and provide an algorithm, based on the reasoning system, for producing diagrams in our normal ...
Simon Thompson, John Taylor, Taylor, John, Gem Stapleton, Delaney, Aidan, Thompson, Simon, Stapleton, Gem, Aidan Delaney   +7 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Energy methods for lossless systems using quadratic differential forms

, 2008
In this thesis, we study the properties of lossless systems using the concept of quadratic differential forms (QDFs). Based on observation of physical linear lossless systems, we define a lossless system as one for which there exists a QDF known as an ...
Rao, Shodhan
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Equivariant singularity theory with distinguished parameters: Two case studies of resonant Hamiltonian systems [PDF]

, 1998
We consider Hamiltonian systems near equilibrium that can be (formally) reduced to one degree of freedom. Spatio-temporal symmetries play a key role. The planar reduction is studied by equivariant singularity theory with distinguished parameters.
Vegter, G, Lunter, Gerard, Lunter, G.A; id_orcid, Vegter, G., G. A. Lunter, Vegter, G.,, Broer, H.W., Vegter, G.; id_orcid, Broer, H.W.,, Broer, H.W.; id_orcid, Lunter, G.A, Lunter, GA, H. W. Broer, G. Vegter, Lunter, G.A.,, Broer, HW   +15 more
core   +1 more source