Results 101 to 110 of about 4,084,972 (304)

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source

Different Combinations of Glucose Tolerance and Blood Pressure Status and Incident Diabetes, Hypertension, and Chronic Kidney Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundThe impact of different combinations of glucose tolerance and blood pressure status on the development of type 2 diabetes mellitus (T2DM), hypertension (HTN), and chronic kidney disease (CKD) still needs to be investigated. Methods and ResultsA
Arash Derakhshan, Farideh Bagherzadeh‐Khiabani, Banafsheh Arshi, Azra Ramezankhani, Fereidoun Azizi, Farzad Hadaegh   +5 more
doaj   +1 more source

tolerance: An R Package for Estimating Tolerance Intervals [PDF]

The tolerance package for R provides a set of functions for estimating and plotting tolerance limits. This package provides a wide-range of functions for estimating discrete and continuous tolerance intervals as well as for estimating regression ...
Derek S. Young
core  

Generalised stochastic model for characterisation of subcutaneous glucose time series [PDF]

, 2014
A generalised stochastic model with second order differential equations is proposed to describe the response of blood glucose concentration to meals in groups of nondiabetic people and two types of diabetic patients.
Holt, Tim A., Khovanova, N. A., Tim A. Holt, Yan Zhang, Zhang, Yan, Natasha Khovanova   +5 more
core   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Smoking, white blood cell counts, and TNF system activity in Japanese male subjects with normal glucose tolerance [PDF]

, 2011
Background Cigarette smokers have increased white blood cell (WBC) counts and the activation of tumor necrosis factor (TNF). The effect of smoking on WBC counts and TNF system activity, however, has not been separately investigated yet.
Naoya Watanabe, Yoshikatsu Nakai, Shoichiro Nagasaka, Ataru Taniguchi, Takahide Okumura, Sae Aoyama, Ryoichi Ohtsubo, Mitsuo Fukushima, Yoshio Nomura, Daisuke Yabe, Fusanori Nishimura, Yoshio Izumi   +11 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Beta Cell Function, Insulin Resistance and Low Grade Systemic Inflammation in Myanmar Adults with Different Categories of Glucose Tolerance

Journal of the ASEAN Federation of Endocrine Societies, 2014
Objective. The aim of the study was to evaluate the beta cell function, insulin sensitivity and low grade systemic inflammation in different categories of glucose tolerance in Myanmar.   Methodology.
Mo-Mo- Than, May Thazin, Tint Swe Latt
doaj  

Macrosomia in non–gestational diabetes pregnancy: glucose tolerance test characteristics and feto–maternal complications in tropical Asia Pacific Australia

Asian Pacific Journal of Tropical Biomedicine, 2014
Objective: To look into the glucose tolerance test characteristics and determine complications in non-gestational diabetes pregnant subjects. Methods: From 2006 to 2009 all non-gestational diabetes mellitus (non-GDM) pregnant women who delivered ...
Algenes Aranha, Usman H Malabu, Venkat Vangaveti, Elham Saleh Reda, Yong Mong Tan, Kunwarjit Singh Sangla   +5 more
doaj   +1 more source

Morning cortisol is lower in obese individuals with normal glucose tolerance

, 2011
Edavan P Praveen1, Jaya Prakash Sahoo1, Bindu Kulshreshtha2, Madan L Khurana3, Nandita Gupta1, Sada Nand Dwivedi3, Guresh Kumar3, Ariachery C Ammini11Department of Endocrinology, All India Institute of Medical Sciences, 2Ram Manohar Lohia Hospital ...
Kumar G, Khurana ML, Dwivedi SN, Kulshreshtha B, Sahoo JP, Gupta N, Praveen EP, Ammini AC   +7 more
core