Results 71 to 80 of about 1,017,506 (258)

Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice.

PLoS ONE, 2010
Approximately half of cancer-affected patients receive radiotherapy (RT). The doses delivered have been determined upon empirical experience based upon average radiation responses.
Huiling Xu, Kuhendra Balakrishnan, Jordane Malaterre, Matthew Beasley, Yuqian Yan, Jeroen Essers, Esther Appeldoorn, Jonathan M Tomaszewski, Melisa Vazquez, Sandra Verschoor, Martin F Lavin, Ivan Bertoncello, Robert G Ramsay, Michael J McKay   +13 more
doaj   +1 more source

MODELING OF RING-SLOT-ELEMENT FLOQUET CELL FOR REFLECTARRAY ANTENNAS

Известия высших учебных заведений России: Радиоэлектроника, 2018
The ring-slot-element cell for reflectarray antennas is investigated. The mathematical model of the unit cell is based on the integral equation that is solved by the moment method with the use of the spectral domain Green’s function.
Svyatoslav V. Ballandovich, Grigory A. Kostikov, Yury G. Antonov, Liubov M. Liubina   +3 more
doaj   +1 more source

Application of Low-Intensity Laser in the Treatment of Skeletal Muscle Injury in Runners

Emergency Medicine International, 2022
With the continuous improvement of people’s economic level, running, as the most common sports, is not limited by sports venues and sports levels and deeply loved by people. However, during running, soft tissue resonates with the impact force, increasing
Youdong Chen, Qiang Li
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

On the stable approximate solution of the ill-posed boundary value problem for the Laplace equation with homogeneous conditions of the second kind on the edges at inaccurate data on the approximated boundary

Discrete and Continuous Models and Applied Computational Science
In this paper, we consider the ill-posed continuation problem for harmonic functions from an ill-defined boundary in a cylindrical domain with homogeneous boundary conditions of the second type on the side faces.
Evgeniy B. Laneev, Alexander V. Klimishin   +1 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Monitoring indexes of concrete dam based on correlation and discreteness of multi-point displacements.

PLoS ONE, 2018
Monitoring indexes are significant for real-time monitoring of dam performance in ensuring safe and normal operation. Traditional methods for establishing monitoring indexes are mostly focused on single point displacements, and rational monitoring ...
Xiangnan Qin, Chongshi Gu, Erfeng Zhao, Bo Chen, Yanling Yu, Bo Dai   +5 more
doaj   +1 more source

Integral cohomology of the Generalized Kummer fourfold

, 2017
We describe the integral cohomology of the Generalized Kummer fourfold giving an explicit basis, using Hilbert scheme cohomology and tools developed by Hassett and Tschinkel.
Kapfer, Simon, Menet, Grégoire
core   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source