Results 101 to 110 of about 585,422 (289)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Violation of LGtI inequalities in the light of NO $$\nu $$ ν A and T2K anomaly

European Physical Journal C: Particles and Fields
The recent anomaly observed in NO $$\nu $$ ν A and T2K experiments in standard three-flavor neutrino oscillation could potentially signal physics extending beyond the standard model (SM).
Lekhashri Konwar, Juhi Vardani, Bhavna Yadav   +2 more
doaj   +1 more source

A novel approach to quantifying the sensitivity of current and future cosmological datasets to the neutrino mass ordering through Bayesian hierarchical modeling

Physics Letters B, 2017
We present a novel approach to derive constraints on neutrino masses, as well as on other cosmological parameters, from cosmological data, while taking into account our ignorance of the neutrino mass ordering.
Martina Gerbino, Massimiliano Lattanzi, Olga Mena, Katherine Freese   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Termination of rewriting strategies: a generic approach [PDF]

, 2005
We propose a generic termination proof method for rewriting under strategies, based on an explicit induction on the termination property. Rewriting trees on ground terms are modeled by proof trees, generated by alternatively applying narrowing and ...
Gnaedig, Isabelle, Kirchner, Helene
core   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

More models for lepton mixing with four constraints

Journal of High Energy Physics, 2019
We propose new lepton-mixing textures that may be enforced through well-defined symmetries in renormalizable models. Each of our textures has four sum rules for the neutrino mass observables.
Darius Jurčiukonis, Luís Lavoura
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Predictive Pati-Salam theory of fermion masses and mixing

Journal of High Energy Physics, 2017
We propose a Pati-Salam extension of the standard model incorporating a flavor symmetry based on the Δ (27) group. The theory realizes a realistic Froggatt-Nielsen picture of quark mixing and a predictive pattern of neutrino oscillations.
A. E. Cárcamo Hernández, Sergey Kovalenko, José W. F. Valle, C. A. Vaquera-Araujo   +3 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source