Results 101 to 110 of about 586,193 (290)

Termination of rewriting strategies: a generic approach [PDF]

, 2005
We propose a generic termination proof method for rewriting under strategies, based on an explicit induction on the termination property. Rewriting trees on ground terms are modeled by proof trees, generated by alternatively applying narrowing and ...
Gnaedig, Isabelle, Kirchner, Helene
core   +4 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

An SU(5)×A5 golden ratio flavour model

Nuclear Physics B, 2015
In this paper we study an SU(5)×A5 flavour model which exhibits a neutrino mass sum rule and golden ratio mixing in the neutrino sector which is corrected from the charged lepton Yukawa couplings.
Julia Gehrlein, Jens P. Oppermann, Daniela Schäfer, Martin Spinrath   +3 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Violation of LGtI inequalities in the light of NO $$\nu $$ ν A and T2K anomaly

European Physical Journal C: Particles and Fields
The recent anomaly observed in NO $$\nu $$ ν A and T2K experiments in standard three-flavor neutrino oscillation could potentially signal physics extending beyond the standard model (SM).
Lekhashri Konwar, Juhi Vardani, Bhavna Yadav   +2 more
doaj   +1 more source

A novel approach to quantifying the sensitivity of current and future cosmological datasets to the neutrino mass ordering through Bayesian hierarchical modeling

Physics Letters B, 2017
We present a novel approach to derive constraints on neutrino masses, as well as on other cosmological parameters, from cosmological data, while taking into account our ignorance of the neutrino mass ordering.
Martina Gerbino, Massimiliano Lattanzi, Olga Mena, Katherine Freese   +3 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

More models for lepton mixing with four constraints

Journal of High Energy Physics, 2019
We propose new lepton-mixing textures that may be enforced through well-defined symmetries in renormalizable models. Each of our textures has four sum rules for the neutrino mass observables.
Darius Jurčiukonis, Luís Lavoura
doaj   +1 more source