Results 111 to 120 of about 15,343,912 (311)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The fate of hints: updated global analysis of three-flavor neutrino oscillations

Journal of High Energy Physics, 2020
Our herein described combined analysis of the latest neutrino oscillation data presented at the Neutrino2020 conference shows that previous hints for the neutrino mass ordering have significantly decreased, and normal ordering (NO) is favored only at the
Ivan Esteban, M.C. Gonzalez-Garcia, Michele Maltoni, Thomas Schwetz, Albert Zhou   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Proof normalization for a first-order formulation of higher-order logic [PDF]

, 1997
We define a notion of cut and a proof reduction process for a class of theories, including all equational theories and a first-order formulation of higher-order logic. Proofs normalize for all equational theories. We show that the proof of the normalization theorem for the usual formulation of higher-order logic can be adapted to prove normalization ...
openaire   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Lessons from the first JUNO results

Journal of High Energy Physics
First results from the JUNO reactor neutrino experiment already determine with world-leading precision the small neutrino squared-mass splitting ∆ m 21 2 $$ \Delta {m}_{21}^2 $$ and the mixing angle θ 12.
Ivan Esteban, M. C. Gonzalez-Garcia, Michele Maltoni, Ivan Martinez-Soler, João Paulo Pinheiro, Thomas Schwetz   +5 more
doaj   +1 more source

An SU(5)×A5 golden ratio flavour model

Nuclear Physics B, 2015
In this paper we study an SU(5)×A5 flavour model which exhibits a neutrino mass sum rule and golden ratio mixing in the neutrino sector which is corrected from the charged lepton Yukawa couplings.
Julia Gehrlein, Jens P. Oppermann, Daniela Schäfer, Martin Spinrath   +3 more
doaj   +1 more source

Termination of rewriting strategies: a generic approach [PDF]

, 2005
We propose a generic termination proof method for rewriting under strategies, based on an explicit induction on the termination property. Rewriting trees on ground terms are modeled by proof trees, generated by alternatively applying narrowing and ...
Gnaedig, Isabelle, Kirchner, Helene
core   +4 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source