Results 101 to 110 of about 15,343,912 (311)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Probing neutrino mass ordering with supernova neutrinos at NOνA including the effect of sterile neutrinos

Nuclear Physics B
In this work, we explore the possibility of probing the mass ordering sensitivity as a function of supernova distance in the context of the ongoing neutrino experiment NOνA.
Papia Panda, Rukmani Mohanta
doaj   +1 more source

Thickness-dependent cation order and disorder in PbSc0.5Ta0.5O3 thin films grown by pulsed laser deposition

New Journal of Physics, 2014
We report on thickness-dependent cation ordering and ferroelectric properties of (001)-oriented epitaxial PbSc _0.5 Ta _0.5 O _3 (PST) thin films grown by pulsed laser deposition on SrTiO _3 (001) and Si (001) substrates.
Anuj Chopra, Balaji I Birajdar, Andreas Berger, Marin Alexe, Dietrich Hesse   +4 more
doaj   +1 more source

Pretest expectations strongly influence interpretation of abnormal laboratory results and further management

BMC Family Practice, 2010
Background Abnormal results of diagnostic laboratory tests can be difficult to interpret when disease probability is very low. Although most physicians generally do not use Bayesian calculations to interpret abnormal results, their estimates of pretest ...
Winkens Ron AG, Winkens Bjorn, van der Weijden Trudy, Houben Paul HH, Grol Richard PTM   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Exploring atmospheric neutrino oscillations at ESSnuSB

Journal of High Energy Physics
This study provides an analysis of atmospheric neutrino oscillations at the ESSnuSB far detector facility. The prospects of the two cylindrical Water Cherenkov detectors with a total fiducial mass of 540 kt are investigated over 10 years of data taking ...
The ESSnuSB collaboration, J. Aguilar, M. Anastasopoulos, E. Baussan, A. K. Bhattacharyya, A. Bignami, M. Blennow, M. Bogomilov, B. Bolling, E. Bouquerel, F. Bramati, A. Branca, G. Brunetti, I. Bustinduy, C. J. Carlile, J. Cederkall, T. W. Choi, S. Choubey, P. Christiansen, M. Collins, E. Cristaldo Morales, P. Cupiał, H. Danared, J. P. A. M. de André, M. Dracos, I. Efthymiopoulos, T. Ekelöf, M. Eshraqi, G. Fanourakis, A. Farricker, E. Fasoula, T. Fukuda, N. Gazis, Th. Geralis, M. Ghosh, A. Giarnetti, G. Gokbulut, C. Hagner, L. Halić, M. Hooft, K. E. Iversen, N. Jachowicz, M. Jenssen, R. Johansson, E. Kasimi, A. Kayis Topaksu, B. Kildetoft, K. Kordas, A. Leisos, M. Lindroos, A. Longhin, C. Maiano, S. Marangoni, C. Marrelli, D. Meloni, M. Mezzetto, N. Milas, J. L. Muñoz, K. Niewczas, M. Oglakci, T. Ohlsson, M. Olvegård, M. Pari, D. Patrzalek, G. Petkov, Ch. Petridou, P. Poussot, A. Psallidas, F. Pupilli, D. Saiang, D. Sampsonidis, C. Schwab, F. Sordo, A. Sosa, G. Stavropoulos, R. Tarkeshian, F. Terranova, T. Tolba, E. Trachanas, R. Tsenov, A. Tsirigotis, S. E. Tzamarias, G. Vankova-Kirilova, N. Vassilopoulos, S. Vihonen, J. Wurtz, V. Zeter, O. Zormpa   +87 more
doaj   +1 more source

Constraining the Effective Mass of Majorana Neutrino with Sterile Neutrino Mass for Inverted Ordering Spectrum

Advances in High Energy Physics, 2019
Inspired by the experimental anomalies in neutrino physics and recent oscillation data from short baseline and another neutrino experiment, the realization of one extra neutrino flavor seems to be favoring.
Jaydip Singh
doaj   +1 more source

Tadpoles, Cephalopods, and ‘Complete Normal Ordering [PDF]

Proceedings of 18th International Conference From the Planck Scale to the Electroweak Scale — PoS(PLANCK 2015), 2016
10 pages, 18th International Conference From the Planck Scale to the Electroweak ...
openaire   +2 more sources