Results 111 to 120 of about 586,193 (290)
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Predictive Pati-Salam theory of fermion masses and mixing
Journal of High Energy Physics, 2017 We propose a Pati-Salam extension of the standard model incorporating a flavor symmetry based on the Δ (27) group. The theory realizes a realistic Froggatt-Nielsen picture of quark mixing and a predictive pattern of neutrino oscillations.
A. E. Cárcamo Hernández +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Recent developments in combinatorial aspects of normal ordering [PDF]
Enumerative Combinatorics and Applications, 2021 Matthias Schork
doaj
Still another approach to the braid ordering
, 2005 We develop a new approach to the linear ordering of the braid group $B\_n$, based on investigating its restriction to the set $\Div(\Delta\_n^d)$ of all divisors of $\Delta\_n^d$ in the monoid $B\_\infty^+$, i.e., to positive $n$-braids whose normal form
Dehornoy, Patrick
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Orders with a normal basis [PDF]
Czechoslovak Mathematical Journal, 1985 The author proves, using circulant matrices, that if an abelian algebraic number field \(K\) has an integral normal basis then infinitely many orders in \(K\) have such a basis, and notes that if \(K\) has no normal integral basis then no order in \(K\) can have such a basis.
openaire +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source