Results 111 to 120 of about 585,422 (289)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Recent developments in combinatorial aspects of normal ordering [PDF]
Enumerative Combinatorics and Applications, 2021 Matthias Schork
doaj
Still another approach to the braid ordering
, 2005 We develop a new approach to the linear ordering of the braid group $B\_n$, based on investigating its restriction to the set $\Div(\Delta\_n^d)$ of all divisors of $\Delta\_n^d$ in the monoid $B\_\infty^+$, i.e., to positive $n$-braids whose normal form
Dehornoy, Patrick
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Orders with a normal basis [PDF]
Czechoslovak Mathematical Journal, 1985 The author proves, using circulant matrices, that if an abelian algebraic number field \(K\) has an integral normal basis then infinitely many orders in \(K\) have such a basis, and notes that if \(K\) has no normal integral basis then no order in \(K\) can have such a basis.
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A Comparison of MLE for Some Index Distributions Based on Censored Samples
MathematicsThis paper elucidates the prerequisites for maximum likelihood estimation (MLE) of parameters within the exponential and scale parameter families. Estimation of these parameters is predicated on data derived from censored samples and seeks to adhere to ...
Yunhan Liu +4 more
doaj +1 more source
Status of neutrino oscillations 2018: 3σ hint for normal mass ordering and improved CP sensitivity
Physics Letters B, 2018 We present a new global fit of neutrino oscillation parameters within the simplest three-neutrino picture, including new data which appeared since our previous analysis [1].
P.F. de Salas +4 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source