Results 81 to 90 of about 586,193 (290)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Periodic review inventory policy with variable ordering cost, lead time, and backorder rate [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2019 In this paper, a stochastic periodic review inventory model is developed. The backorder rate (backorder price discount), ordering cost (safety stock), lead time, and review period are treated as decision variables. The ordering cost and lead time can be
Nughthoh Arfawi Kurdhi +1 more
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Normalization constants of large order behavior [PDF]
Physics Letters B, 1999 A perturbation scheme is discussed for the computation of the normalization constant of the large order behavior arising from an ultraviolet renormalon. In this scheme the normalization constant is expressed in a convergent series that can be calculated using the ordinary perturbative expansion and the nature of the renormalon singularity.
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
New Journal of Physics, 2014 We report on thickness-dependent cation ordering and ferroelectric properties of (001)-oriented epitaxial PbSc _0.5 Ta _0.5 O _3 (PST) thin films grown by pulsed laser deposition on SrTiO _3 (001) and Si (001) substrates.
Anuj Chopra +4 more
doaj +1 more source
BMC Family Practice, 2010 Background Abnormal results of diagnostic laboratory tests can be difficult to interpret when disease probability is very low. Although most physicians generally do not use Bayesian calculations to interpret abnormal results, their estimates of pretest ...
Winkens Ron AG +4 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Nuclear Physics BIn this work, we explore the possibility of probing the mass ordering sensitivity as a function of supernova distance in the context of the ongoing neutrino experiment NOνA.
Papia Panda, Rukmani Mohanta
doaj +1 more source