Results 101 to 110 of about 3,477,538 (258)

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

open access: yesAdvanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu   +8 more
wiley   +1 more source

Understanding teenage sexuality in Ireland

open access: yes, 2004
Existing research into adolescent sexuality in an Irish context has primarily been conducted using survey methods and these have provided quantitative data on the topic.
Hyde, Abbie, Howlett, Etaoine
core  

Remission during pregnancy of severe Chronic Hypertension due to 11-ß Hydroxylase Deficiency [PDF]

open access: yes, 2004
When hypertension is a result of an underlying identifiable abnormality, the latter's early discovery can lead to a timely cure of the hypertension and the prevention of its complications.
Cachia, Mario J., Attard, Gerhardt
core  

Arterial stiffness in normal pregnancy as assessed by digital pulse wave analysis by photoplethysmography – A longitudinal study

open access: yes, 2019
Introduction: It might in the future be valuable to screen for increased maternal arterial stiffness, i.e. low compliance, since it is associated with development of hypertensive complications in pregnancy.
Olofsson, Per,   +3 more
core   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

open access: yesAdvanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo   +14 more
wiley   +1 more source

Narratives of the Pregnant Body: The Stories of Women in the Latter Stages of Pregnancy [PDF]

open access: yes, 2002
Becoming a mother is conceptualised as an important life transition in the social sciences. In this chapter I present narratives of six women in the latter stages of pregnancy.
Johnson, Sally
core   +2 more sources

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

open access: yesAdvanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu   +11 more
wiley   +1 more source

Men, sexuality and crisis pregnancy: A study of men’s experiences

open access: yes, 2007
This research report was commissioned by the Crisis Pregnancy Agency with the overall aim of increasing understanding of men, sexuality and crisis pregnancy.
Hogan, Fergus, Ferguson, Harry
core  

Multiscale Coupling From Mastication to Retronasal Aroma Perception: The PG‐DTCFN Model and Multiphysics Simulation

open access: yesAdvanced Science, EarlyView.
Using grilled lamb skewers as a model system, this work builds a multiscale coupling framework from oral processing to retronasal aroma perception, reveals dual‐kinetic release patterns and Electroencephalogram‐characterized central encoding features, and proposes an interpretable physics‐guided deep learning model validated by multiphysics simulation,
Che Shen   +12 more
wiley   +1 more source

Improving knowledge regarding abortions performed on Irish women in the UK

open access: yes, 2007
The overall aim of this study was to provide detailed statistics on women who travel from Ireland1 to Great Britain for an abortion. This was done by using data on abortion notifications held by the Department of Health in London, plus data available ...
Clements, Steve, Ingham, Roger
core  

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