Global transcriptional response of oral squamous cell carcinoma cell lines to health-associated oral bacteria - an in vitro study [PDF]
Journal of Oral Microbiology, 2022 Background We have recently demonstrated that health-associated oral bacteria Streptococcus mitis, Neisseria flavescens, and Haemophilus parainfluenzae induce cytotoxicity in oral squamous cell carcinoma (OSCC) cell lines and downregulate CD36, a cancer ...
Divyashri Baraniya +2 more
doaj +2 more sources
The Role of p66Shc in Diabetes: A Comprehensive Review from Bench to Bedside. [PDF]
J Diabetes Res, 2022 It is well‐documented that diabetes is an inflammatory and oxidative disease, with an escalating global burden. Still, there is no definite treatment for diabetes or even prevention of its harmful complications. Therefore, understanding the molecular pathways associated with diabetes might help in finding a solution.
Mousavi S +5 more
europepmc +2 more sources
Nkx2.7 is a conserved regulator of craniofacial development [PDF]
Nature CommunicationsCraniofacial malformations arise from developmental defects in the head, face, and neck with phenotypes such as 22q11.2 deletion syndrome illustrating a developmental link between cardiovascular and craniofacial morphogenesis.
Caitlin Ford +16 more
doaj +2 more sources
Brain Renin-Angiotensin System: From Physiology to Pathology in Neuronal Complications Induced by SARS-CoV-2. [PDF]
Anal Cell Pathol (Amst), 2023 Angiotensin‐converting enzyme 2 (ACE2), a key enzyme in the renin–angiotensin system (RAS), is expressed in various tissues and organs, including the central nervous system (CNS). The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus responsible for coronavirus disease‐2019 (COVID‐19), binds to ACE2, which raises ...
Ahmadi S, Khaledi S.
europepmc +2 more sources
Pathophysiology of systemic sclerosis (scleroderma). [PDF]
Kaohsiung J Med Sci, 2022 Abstract Systemic sclerosis (scleroderma) is an autoimmune‐triggered chronic fibrosing disease that affects the skin and many other organs. Its pathophysiology is complex and involves an early endothelial damage, an inflammatory infiltrate and a resulting fibrotic reaction.
Rosendahl AH, Schönborn K, Krieg T.
europepmc +2 more sources
The Subchronic Toxic Effects of Mosla chinensis Maxim in Normal Rats. [PDF]
Biomed Res Int, 2020 Background. The aim of this work was to study the toxic effects and target organs of Mosla chinensis Maxim (MCM) in rats and provide theoretical basis for clinical medication. Methods. The subchronic toxicity study was conducted on 60 male and female SD rats using the fixed‐dose method for the treatment groups and 20 male and female SD rats for the ...
Lei D +9 more
europepmc +2 more sources
Competition between Jagged-Notch and Endothelin1 Signaling Selectively Restricts Cartilage Formation in the Zebrafish Upper Face [PDF]
PLoS Genetics, 2016 The intricate shaping of the facial skeleton is essential for function of the vertebrate jaw and middle ear. While much has been learned about the signaling pathways and transcription factors that control facial patterning, the downstream cellular ...
Amjad Askary +2 more
exaly +2 more sources
Intercellular Genetic Interaction Between Irf6 and Twist1 during Craniofacial Development [PDF]
Scientific Reports, 2017 Interferon Regulatory Factor 6 (IRF6) and TWIST1 are transcription factors necessary for craniofacial development. Human genetic studies showed that mutations in IRF6 lead to cleft lip and palate and mandibular abnormalities.
Walid D. Fakhouri +7 more
doaj +2 more sources
Loss of CEACAM1 in endothelial cells causes hepatic fibrosis [PDF]
Metabolism: Clinical and Experimental, 2023 Harrison T Muturi +2 more
exaly +2 more sources
Mesenchymal stem cells: A novel treatment option for primary sclerosing cholangitis
Cell Biology International, Volume 47, Issue 2, Page 467-479, February 2023., 2023 Abstract Primary sclerosing cholangitis (PSC) is a progressive liver disease for which there is no effective therapy. Hepatocytes and cholangiocytes from a PSC patient were cocultured with mesenchymal stem cells (MSCs) to assess in vitro change. A single patient with progressive PSC was treated with 150 million MSCs via direct injection into the common
Amy L. Lightner +8 more
wiley +1 more source