Results 31 to 40 of about 812 (122)
International Journal of Rheumatology, Volume 2010, Issue 1, 2010., 2010 Peripheral microvascular impairment in systemic sclerosis (SSc) may be easily detected and scored in a safe noninvasive way by nailfold videocapillaroscopy (NVC). The paper highlights clinical conditions related to SSc in which NVC may represent an outcome measure of therapeutical interventions, by elaborating on their already assessed relationship ...
Maurizio Cutolo +4 more
wiley +1 more source
Scientific Reports, 2018 Individuals with Trisomy 21 (T21) exhibit numerous hematological abnormalities, including reductions in numbers of circulating B and T lymphocytes. To elucidate molecular mechanisms underlying these phenotypes, we differentiated human isogenic disomic ...
Glenn A. MacLean +5 more
doaj +1 more source
Endothelin-1 Inhibits Apoptosis in Prostate Cancer
Neoplasia: An International Journal for Oncology Research, 2005 Endothelin-1 (ET-1), produced by the prostate epithelia, likely plays an important role in the progression of prostate cancer. ET-1 can bind two receptor subtypes; generally, binding of the endothelin receptor A (ETA) induces a survival pathway, whereas ...
Joel B. Nelson +3 more
doaj +1 more source
BioMed Research International, Volume 2010, Issue 1, 2010., 2010 Endothelin1 (ET‐1) is a 21‐amino acid peptide produced by the vascular endothelium under hypoxia, that acts locally as regulator of vascular tone and inflammation. The role of ET‐1 in Plasmodium falciparum malaria is unknown, although tissue hypoxia is frequent as a result of the cytoadherence of parasitized red blood cell (pRBC) to the ...
Nicoletta Basilico +8 more
wiley +1 more source
Association of Big Endothelin-1 with Coronary Artery Calcification. [PDF]
PLoS ONE, 2015 The coronary artery calcification (CAC) is clinically considered as one of the important predictors of atherosclerosis. Several studies have confirmed that endothelin-1(ET-1) plays an important role in the process of atherosclerosis formation. The aim of
Ping Qing +8 more
doaj +1 more source
Increase in endothelin-1 expression in umbilical cord vessels in preeclampsia
Siriraj Medical Journal, 2020 INTRODUCTION: Endothelin1 (ET1) is 21- amino acid vasoconstrictor peptide secreted by endotheliumwhich has an important role in the pathoohysiology of preeclampsia (PE).
Safa A. K. Algobori +7 more
doaj
Loss of CEACAM1 in hepatocytes causes hepatic fibrosis
European Journal of Clinical Investigation, Volume 54, Issue 7, July 2024.Abstract Background The role of insulin resistance in hepatic fibrosis in Metabolic dysfunction‐Associated SteatoHepatitis (MASH) remains unclear. Carcinoembryonic Antigen‐related Cell Adhesion Molecule1 protein (CEACAM1) promotes insulin clearance to maintain insulin sensitivity and repress de novo lipogenesis, as bolstered by the development of ...
Sobia Zaidi +16 more
wiley +1 more source
Binding of Endothelin-1 To Human Blood Monocyte
Majalah Kedokteran Bandung, 2009 Monocyte attachment to the endothelium and migration into the vessel intima are the initiating steps in atherogenesis. This is thought to be facilitated by endothelin-1 (ET-1) as a potent chemoattractant to human blood monocytes.
Tri Hanggono Achmad, Govind S. Rao
doaj +1 more source
Ulinastatin alleviates traumatic brain injury by reducing endothelin-1
Translational Neuroscience, 2020 Brain edema is one of the major causes of fatality and disability associated with injury and neurosurgical procedures. The goal of this study was to evaluate the effect of ulinastatin (UTI), a protease inhibitor, on astrocytes in a rat model of traumatic
Liu Ting, Liao Xing-Zhi, Zhou Mai-Tao
doaj +1 more source
Role of endothelin-1 in lung disease
Respiratory Research, 2001 Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of smooth muscle tone, and inflammatory mediator that may play a key role in diseases of the
Rodman David M +2 more
doaj +1 more source