Results 11 to 20 of about 812 (122)

Circulating Levels of Endothelin-1 and Big Endothelin-1 in Patients with Essential Hypertension

Pathophysiology, 2021
The role of endothelin-1 (ET-1) in the pathogenesis of hypertension (HTN) is not clearly established. There is evidence that its circulating levels are elevated in some forms of experimental and human HTN, but this was not a consistent finding.
Krasimir Kostov, Alexander Blazhev
doaj   +1 more source

Novel insight into the role of clusterin on intraocular pressure regulation by modifying actin polymerization and extracellular matrix remodeling in the trabecular meshwork

Journal of Cellular Physiology, Volume 237, Issue 7, Page 3012-3029, July 2022., 2022
This study identifies the role of clusterin on the actin cytoskeleton and extracellular matrix remodeling in the trabecular meshwork. We found that a loss of clusterin function induced actin polymerization, the levels of focal adhesions and integrins, and elevated intraocular pressure (IOP) signifying the importance of clusterin in IOP homeostasis ...
Avinash Soundararajan, Ting Wang, Sachin A. Ghag, Min H. Kang, Padmanabhan P. Pattabiraman   +4 more
wiley   +1 more source

Systems biology of angiogenesis signaling: Computational models and omics

WIREs Mechanisms of Disease, Volume 14, Issue 4, July/August 2022., 2022
Multiscale and multicellular regulation of angiogenesis signaling (created with BioRender.com). Abstract Angiogenesis is a highly regulated multiscale process that involves a plethora of cells, their cellular signal transduction, activation, proliferation, differentiation, as well as their intercellular communication.
Yu Zhang, Hanwen Wang, Rebeca Hannah M. Oliveira, Chen Zhao, Aleksander S. Popel   +4 more
wiley   +1 more source

Pathophysiology of systemic sclerosis (scleroderma)

The Kaohsiung Journal of Medical Sciences, Volume 38, Issue 3, Page 187-195, March 2022., 2022
Abstract Systemic sclerosis (scleroderma) is an autoimmune‐triggered chronic fibrosing disease that affects the skin and many other organs. Its pathophysiology is complex and involves an early endothelial damage, an inflammatory infiltrate and a resulting fibrotic reaction.
Ann‐Helen Rosendahl, Katrin Schönborn, Thomas Krieg   +2 more
wiley   +1 more source

HISTOMORPHOMETRIC AND ENDOTHELIN-1 IMMUNOHISTOCHEMICAL STUDY OF HUMAN PLACENTAL VILLI CORRELATED WITH UMBILICAL CORD COILING INDEX

The Iraqi Journal of Medical Sciences, 2017
Background: Umbilical cord coiling index plays a role in predicting the pregnancy outcome and risk of low birth weight. Endothelin-1 binding sites exist on placental stem villi vessels and trophoblastic layer of the villi.
Hayder J. Mubarak, Sarah A. Ahmed
doaj   +6 more sources

Increase in Endothelin-1 Expression in Umbilical Cord Arteries in Preeclampsia

Siriraj Medical Journal, 2020
Objective: Endothelin1 (ET1) is 21- amino acid vasoconstrictor peptide secreted by endotheliumwhich has an important role in the pathoohysiology of preeclampsia (PE).  The objective of this study was to evaluate the binding sites and quantitative changes
Safa A. K. Algobori, May F. Alhabib, Manal T. Alobaidy, Imad M. Al-Ani, Enas I. Matloup, Ghasak G. Faisal, Mohammad O. Selman, Azhar M. Suhail   +7 more
doaj   +1 more source

DEspR roles in tumor vasculo-angiogenesis, invasiveness, CSC-survival and anoikis resistance: a 'common receptor coordinator' paradigm. [PDF]

PLoS ONE, 2014
A priori, a common receptor induced in tumor microvessels, cancer cells and cancer stem-like cells (CSCs) that is involved in tumor angiogenesis, invasiveness, and CSC anoikis resistance and survival, could underlie contemporaneous coordination of these ...
Victoria L Herrera, Julius L Decano, Glaiza A Tan, Ann M Moran, Khristine A Pasion, Yuichi Matsubara, Nelson Ruiz-Opazo   +6 more
doaj   +1 more source

Developmental aspects of the tympanic membrane: Shedding light on function and disease

genesis, Volume 58, Issue 3-4, March‐April 2020., 2020
Summary The ear drum, or tympanic membrane (TM), is a key component in the intricate relay that transmits air‐borne sound to our fluid‐filled inner ear. Despite early belief that the mammalian ear drum evolved as a transformation of a reptilian drum, newer fossil data suggests a parallel and independent evolution of this structure in mammals. The term “
Mona Mozaffari, Dan Jiang, Abigail S. Tucker   +2 more
wiley   +1 more source

Elevated aqueous endothelin-1 concentrations in advanced diabetic retinopathy.

PLoS ONE, 2022
PurposeEndothelin-1 (ET-1) is a potent vasoconstrictor which seems to be involved in the pathogenesis of diabetic retinopathy (DR). However, studies on intraocular ET-1 in DR have been limited.
Hae Min Kang, Md Hasanuzzaman, So Won Kim, Hyoung Jun Koh, Sung Chul Lee   +4 more
doaj   +2 more sources

Mandibular Explant Assay for Investigating Extrinsic Stimuli on Bone and Cartilage Development

Bio-Protocol, 2017
A major issue in developmental biology is to determine how embryonic tissues respond to molecular signals in a timely manner and given the position-restricted instructions during morphogenesis, of which Meckel’s cartilage is a classical example.
Jamie Jiang, Jessica Bertol, Walid Fakhouri   +2 more
doaj   +1 more source