Results 161 to 170 of about 989,931 (304)

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, EarlyView.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source

The role of complement in normal pregnancy and preeclampsia. [PDF]

Front Immunol
Burwick RM, Java A, Regal JF.
europepmc   +1 more source

Investigating protein C and S levels in pregnant women with recurrent early pregnancy loss versus normal pregnancy. [PDF]

J Med Life, 2023
Mukhtar B, Garg R, Ibrahim G, Batra J.
europepmc   +1 more source

Glycosylated haemoglobins in normal pregnancy [PDF]

Diabetologia, 1985
K, Ylinen, U H, Stenman, R, Hekali, T, Kesäniemi-Kuokkanen, K, Teramo   +4 more
openaire   +2 more sources

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

A Case of Ectopic Pregnancy With an Unusually High Level of β-hCG Correlating With Normal Pregnancy. [PDF]

Cureus
Al-Rufaye FA, Desouki B.
europepmc   +1 more source

Longitudinal assessment of spiral and uterine arteries in normal pregnancy using novel ultrasound tool. [PDF]

Ultrasound Obstet Gynecol, 2023
Horgan R, Sinkovskaya E, Saade G, Kalafat E, Rice MM, Heeze A, Abuhamad A.   +6 more
europepmc   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Longitudinal assessment of fetal myocardial performance index in normal pregnancy using spectral tissue Doppler. [PDF]

Ultrasound Obstet Gynecol
Horgan R, Sinkovskaya E, Kalafat E, Saade G, Abuhamad A.   +4 more
europepmc   +1 more source