Results 41 to 50 of about 989,931 (304)

Pathological pregnancy and psychological symptoms in women [Patološka trudnoća i psihički simptomi u žena] [PDF]

, 2012
Pregnancy is followed by many physiologic, organic and psychological changes and disorders, which can become more serious in pregnancy followed by complications, especially in women with pathological conditions during pregnancy. The purpose of this study
Bjelanović, Vedran, Babić, Dragan, Orešković, Slavko, Tomić, Vajdana, Martinac, Marko, Juras, Josip   +5 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women [PDF]

, 2014
Background This study was undertaken to characterize the vaginal microbiota throughout normal human pregnancy using sequence-based techniques. We compared the vaginal microbial composition of non-pregnant patients with a group of pregnant women who ...
Chaemsaithong, Piya, Chaiworapongsa, Tinnakorn, Fadrosh, Douglas W, Gajer, Pawel, Galuppi, Marisa, Hassan, Sonia S, Lamont, Ronald F, Miranda, Jezid, Nikita, Lorraine, Ravel, Jacques, Romero, Roberto, Tarca, Adi L   +11 more
core   +5 more sources

Intra-uterine fetal demise caused by amniotic band syndrome after standard amniocentesis [PDF]

, 2000
The amniotic band syndrome represents a prime example of exogenous disruption of an otherwise normal feta I development. It may be a sequel of invasive diagnostic procedures such as amniocentesis or fetal blood sampling. A 38-year-old gravida II, para II
Bauerfeind, I., Hasbargen, U., Hepp, Hermann, Paek, Bettina, Strauss, Alexander   +4 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Course of neuromyelitis optica during inadvertent pregnancy in a patient treated with rituximab [PDF]

, 2009
In neuromyelitis optica (NMO), the monoclonal B-cell antibody rituximab is a therapeutic option. Little is known about the course of NMO and the safety of rituximab during pregnancy.
Hohlfeld, R., Kümpfel, Tania, Pellkofer, H. L., Schulze, A., Suessmair, C.   +4 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A study on structural changes of placenta in pregnancy induced hypertensive pregnancies in eastern India [PDF]

Al Ameen Journal of Medical Sciences
Background: Complications of pregnancy are reflected in placenta. Placenta is the mirror of maternal and foetal status. So a study of placenta and new born will help to identify the disease by which mother is affected in pregnancies of pregnancy induced ...
Biswanath Baskey, Ratnadeep Poddar, Iman Sinha, Joydip Saha, Akash Kusum Banerjee   +4 more
doaj  

Viral Infections and Spontaneous Abortion in Women: A Case-Control Study [PDF]

Journal of Kerman University of Medical Sciences
Background: Spontaneous abortion before the 20th week, a prevalent pregnancy complication, is often linked to intrauterine viral infections. This study aims to identify DNA viruses in placental tissue from women with spontaneous abortion and full-term ...
Maryam Yarabbi, Mohsen Nakhaie, elham Jafari Maskouni, Elham Mousavi, narges karimi, Ali Mohammad Arabzadeh, nasim Pordamghan, Saeedeh Ebrahimi   +7 more
doaj   +1 more source