Results 41 to 50 of about 30,703 (243)

Cerebrospinal fluid biomarkers for normal pressure hydrocephalus

Biomarkers in Neuropsychiatry, 2023
Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible disease characterized by gait disturbance, a frontal-subcortical pattern of cognitive impairment, and urinary incontinence with disproportionately enlarged ventricles.
Derya Kaya, Ahmet Turan Isik
doaj   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

Normal Pressure Hydrocephalus: New Concepts [PDF]

Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2008
Normal pressure hydrocephalus is a treatable syndrome seen in elderly patients who show the classical triad of gait disorder, dementia and urinary incontinence. It may be due to idipathic or secondary causes and is a progressive psychomotor disorder.
Mehmet Murat Taşkın
doaj  

Idiopathic Intracranial Hypertension Is Characterized by a Distinct Proteomic Profile

Annals of Neurology, EarlyView.
Objectives The pathophysiology of idiopathic intracranial hypertension (IIH) is poorly understood and disease‐specific biomarkers are lacking. We aimed to shed light on IIH pathophysiology and identify disease‐specific biomarkers. Methods This prospective cross‐sectional cohort study included patients with new‐onset IIH and age‐, body mass index‐, and ...
Santosh D. Bhosale, Arkadiusz Nawrocki, Johanne J. Korsbæk, Nadja S. Hansen, Fabian Foettinger, Nik Krajnc, Mathias J. Norvig, Niclas L. Eriksen, Stefan Macher, Berthold Pemp, Connar S.J. Westgate, Christian B. Pedersen, Frantz R. Poulsen, Sune Munthe, Gabriel Bsteh, Martin R. Larsen, Rigmor H. Jensen, Dagmar Beier   +17 more
wiley   +1 more source

Shunting for idiopathic normal pressure hydrocephalus [PDF]

, 2022
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To determine the effect of cerebrospinal fluid (CSF) shunting versus no CSF shunting in people with idiopathic normal pressure hydrocephalus (iNPH).
Carswell, Christopher, Pearce, Ronald, Richardson, Davina, Tsang, Kevin, Gontsarova, Anastasia, Methley, Abigail M   +5 more
core   +1 more source

Chiari I Malformation: Review and Update of Current Treatment Options

Clinical Anatomy, EarlyView.
ABSTRACT The pathophysiology of Chiari malformation type I (CM‐I) is complex, involving structural abnormalities at the craniovertebral junction that result in herniation of the cerebellar tonsils through the foramen magnum. In this study, we aim to present and evaluate current treatment options for CM‐I, with a focus on evidence‐based clinical ...
Jordan J. Lo, Shuhei Shiino, Stephen Z. Shapiro, Brianna L. Hines, Noritaka Komune, Carmine Antonio Donofrio, Filippo Badaloni, Antonio Fioravanti, Joseph Lockwood, C. J. Bui, Aaron S. Dumont, R. Shane Tubbs   +11 more
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Gait and frontal lobe function become associated in patients with idiopathic normal pressure hydrocephalus after shunt surgery

Frontiers in Neurology
ObjectiveThe association between gait and cognition in older adults is well-established. This study investigated the association between gait and cognition, especially in the frontal lobe, in patients with idiopathic normal pressure hydrocephalus (iNPH).
Masatsune Ishikawa, Masatsune Ishikawa, Etsuro Mori, Hiroaki Kazui   +3 more
doaj   +1 more source

Idiopathic Normal Pressure Hydrocephalus, Case Series [PDF]

Pan Arab Journal of Neurosurgery
Introduction:Idiopathic normal pressure hydrocephalus (iNPH) was first described by Dr Hakim and Dr. Adam on1964 in case series described triad of symptoms of difficult walking, dementia and urine incontinence.
Ahmed Elshanawany, Ahmed Elgheriany, Farrag Mohammad   +2 more
doaj   +1 more source

Investigating idiopathic normal pressure hydrocephalus

, 2017
Hydrocephalus is one of the most common neurosurgical conditions or complications. This is the second paper in the hydrocephalus series. Here, idiopathic normal pressure hydrocephalus (iNPH) will be discussed, focusing on the presenting symptoms ...
Simon D Thompson
core   +1 more source