Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Single-cell RNA-seq data normalization: A benchmarking study. [PDF]
Ge Q, Sheng Y, Lu J, Yang Y, Pan M.
europepmc +1 more source
Disease Entity Recognition and Normalization is Improved with Large Language Model Derived Synthetic Normalized Mentions [PDF]
Kuleen Sasse +3 more
openalex +1 more source
Spatial and temporal variations in Normalized Difference Vegetation Index in Cuba
Daryl David Cruz Flores +3 more
openalex +2 more sources
Normalization of Up‐Regulated Cardiac Imidazoline I1‐Receptors and Natriuretic Peptides by Chronic Treatment with Moxonidine in Spontaneously Hypertensive Rats [PDF]
Rouwayda El‐Ayoubi +3 more
openalex +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Case Report: Exercise-induced normalization of chronic left bundle branch block: a rare recovery-phase phenomenon. [PDF]
Dor-Haim H, Davarashvili I.
europepmc +1 more source
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Mineral Phase-Resolved Quantification in LA-ICP-MS Imaging. [PDF]
Umfahrer B +5 more
europepmc +1 more source
Recognition of Emotions through Facial Geometry with Normalized Landmarks
Alessandra Alaniz Macedo +2 more
openalex +2 more sources

