Results 161 to 170 of about 765,441 (312)

PKIS: practical keyword index search on cloud datacenter

EURASIP Journal on Wireless Communications and Networking, 2011
This paper highlights the importance of the interoperability of the encrypted DB in terms of the characteristics of DB and efficient schemes. Although most prior researches have developed efficient algorithms under the provable security, they do not ...
Park Jae Hyun, Park Hyun-A, Lee Dong Hoon   +2 more
doaj  

Monitoring of tumor vascular normalization: the key points from basic research to clinical application

, 2018
Wei Li,1 Ying-Yao Quan,2 Yong Li,3 Ligong Lu,3 Min Cui1 1Department of General Surgery, Zhuhai People’s Hospital, Jinan University, Zhuhai, Guangdong, People’s Republic of China; 2Department of Precision Medical Center, Zhuhai People’s ...
Li W, Lu L, Li Y, Cui M, Quan Y
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Epigallocatechin-3-gallate-induced vascular normalization in A549-cell xenograft-bearing nude mice: therapeutic efficacy in combination with chemotherapy

, 2019
Pengbo Deng, Chengping Hu, Zeng Xiong, Yuanyuan Li, Juan Jiang, Huaping Yang, Yongjun Tang, Liming Cao, Rongli Lu Department of Respiratory Medicine, Key Site of National Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South ...
Yang H, Cao L, Xiong Z, Jiang J, Hu C, Li Y, Deng P, Tang Y, Lu R   +8 more
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

RxMap: an LLM-assisted tool for medication normalization. [PDF]

JAMIA Open
Korpela E, Rubin LH, Dastgheyb RM, Xu Y.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Orobas: A computational approach for scoring and analysis of quantitative chemical-genetic interactions from CRISPR-Cas9 screens. [PDF]

STAR Protoc
Hassan AZ, Zhang X, Ward HN, Billmann M, Bajjali S, Brown KR, Bhojoo U, Chan K, Lin K, Costanzo M, Andrews B, Boone C, Moffat J, Myers CL.   +13 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Supporting Self-Explanation in a Data

, 2003
Self-explanation is one of the most effective learning strategies, resulting in deep knowledge. In this paper, we discuss how self-explanation is scaffolded in NORMIT, a data normalization tutor.
Antonija Mitrovic, Normalization Tutor Antonija   +1 more
core